ASDCD: antifungal synergistic drug combination database.
ASDCD: antifungal synergistic drug combination database.
复制标题
ASDCD：抗真菌协同药物组合数据库
DOI：
10.1371/journal.pone.0086499
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yan GY
中科院分区：
文献类型：
--
作者：
Chen X;Ren B;Chen M;Liu MX;Ren W;Wang QX;Zhang LX;Yan GY
由于死亡率较高，特别是在免疫缺陷人群中，寻找有效的药物来治疗真菌感染具有重要的临床意义。据报道，传统的单一靶点抗真菌药物会导致严重的副作用和耐药性。然而，如今，药物组合，特别是协同相互作用，已经引起了研究人员的关注。事实上，协同药物组合可以同时影响多个亚群、靶标和疾病。因此，采用协同抗真菌药物组合的策略可以消除上述限制，并提供探索这一新兴生物活性化学空间的机会。然而，首先需要建立一个强大的数据库，以便于药物组合的分析。为了弥补这一知识空白，我们建立了第一个抗真菌协同药物组合数据库（ASCDD），包括之前发布的协同抗真菌药物组合、化学结构、靶点、靶点相关信号通路、适应症和其他相关数据。目前的版本包括210种抗真菌协同药物组合和1225种药物-靶点相互作用，涉及来自12,000多个参考文献的105种单独药物。 ASDCD 可在 http://ASDCD.amss.ac.cn 上免费获取。
Finding effective drugs to treat fungal infections has important clinical significance based on high mortality rates, especially in an immunodeficient population. Traditional antifungal drugs with single targets have been reported to cause serious side effects and drug resistance. Nowadays, however, drug combinations, particularly with respect to synergistic interaction, have attracted the attention of researchers. In fact, synergistic drug combinations could simultaneously affect multiple subpopulations, targets, and diseases. Therefore, a strategy that employs synergistic antifungal drug combinations could eliminate the limitations noted above and offer the opportunity to explore this emerging bioactive chemical space. However, it is first necessary to build a powerful database in order to facilitate the analysis of drug combinations. To address this gap in our knowledge, we have built the first Antifungal Synergistic Drug Combination Database (ASDCD), including previously published synergistic antifungal drug combinations, chemical structures, targets, target-related signaling pathways, indications, and other pertinent data. Its current version includes 210 antifungal synergistic drug combinations and 1225 drug-target interactions, involving 105 individual drugs from more than 12,000 references. ASDCD is freely available at http://ASDCD.amss.ac.cn.
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DOI：
10.1158/1078-0432.ccr-10-1725
发表时间：
2011-02-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Kelly RJ;Draper D;Chen CC;Robey RW;Figg WD;Piekarz RL;Chen X;Gardner ER;Balis FM;Venkatesan AM;Steinberg SM;Fojo T;Bates SE
通讯作者：
Bates SE
影响因子：
7.5
作者：
Borgert, CJ;Borgert, SA;Findley, KC
通讯作者：
Findley, KC
影响因子：
46.9
作者：
Lehar, Joseph;Krueger, Andrew S.;Avery, William;Heilbut, Adrian M.;Johansen, Lisa M.;Price, E. Roydon;Rickles, Richard J.;Short, Glenn F., III;Staunton, Jane E.;Jin, Xiaowei;Lee, Margaret S.;Zimmermann, Grant R.;Borisy, Alexis A.
通讯作者：
Borisy, Alexis A.
DCDB：药物组合数据库
影响因子：
5.8
作者：
Liu, Yanbin;Hu, Bin;Chen, Xin
通讯作者：
Chen, Xin
影响因子：
6.4
作者：
Biran, Anat;Brownstein, Michael;Kloog, Yoel
通讯作者：
Kloog, Yoel