Characterizing alterations in the gut microbiota following postpartum weight change.
Characterizing alterations in the gut microbiota following postpartum weight change.
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DOI：
10.1128/msystems.00808-23
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发表时间：
2023-12-21
期刊：
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
--
作者：
产后时期代表了女性健康的动态时间，特别是在体重变化方面，这可能会不成比例地影响拉丁美洲妇女。体重变化，特别是体重增加，与宿主肠道微生物组特征和组成的显著变化有关。这项研究旨在评估在分娩后的前6个月内体重增加或减轻的拉丁裔母亲肠道微生物组的变化，方法是表征肠道微生物共现网络，α和β多样性指标以及细菌分类群的相对丰度的变化。这项研究描述了105名拉丁裔母亲在产后1个月和6个月的肠道微生物组，比较了在分娩后6个月内体重增加的母亲（n = 65）和体重减轻的母亲（n = 40）。收集粪便样本进行16 S rRNA基因测序。使用微生物共现网络分析以及配对双侧t检验进行统计分析。产后体重增加的母亲与体重减轻的母亲相比，其共生网络密度，α和β多样性以及某些微生物类群的相对丰度发生了显着变化。微生物共现网络，代表群落结构动态差异的措施，体重增加组的密度下降了2%，而体重减轻组的密度没有变化。此外，体重增加组在6个月后具有较低的Shannon熵，并且17个细菌科和属的相对丰度发生了显著变化，而体重减轻组中的任何这些指标都没有显著变化。以前的研究已经报道了与不同身体成分相关的肠道微生物组的差异。更具体地说，在母亲群体中，重点是妊娠期体重增加的影响。这是第一项研究产后体重变化及其与肠道微生物组变化的关系的研究，同样，这是第一项使用拉丁裔队列进行研究的研究。结果支持了这样的观点，即体重增加可能是降低肠道微生物组网络连接性、多样性和改变特定微生物分类群丰度的一个重要因素，所有这些措施都被认为会影响宿主健康。这些结果表明，体重增加在产后的前6个月内动态改变了母亲的肠道微生物群落，而体重减轻的母亲的变化相对较小;需要进一步研究来检查这种变化的健康后果。
The postpartum period represents a dynamic time for women’s health, particularly when it comes to changes in weight, which can disproportionately affect Latina women. Weight change, particularly weight gain, has been associated with pronounced changes in host gut microbiome profiles and composition. This study aimed to evaluate changes in the gut microbiome among Latina mothers who gained or lost weight in the first 6 months after delivery by characterizing changes in gut microbial co-occurrence networks, alpha- and beta-diversity measures, and relative abundances of bacterial taxa. This study characterized the gut microbiomes of 105 Latina mothers at 1 and 6 months postpartum, comparing mothers who gained weight (n = 65) with those who lost weight (n = 40) during the 6-month period following delivery. Stool samples were collected for 16S rRNA gene sequencing. Statistical analysis was conducted using microbial co-occurrence network analysis as well as paired two-sided t-tests. Mothers who gained weight postpartum had significant changes in their co-occurrence network density, alpha- and beta-diversity, and relative abundances of certain microbial taxa compared to those who lost weight. Microbial co-occurrence networks, representing measures of differences in community structure dynamics, of the weight gain group decreased in density by 2%, while there was no change in density in the weight loss group. Additionally, the weight gain group had lower Shannon entropy after 6 months and significant changes in the relative abundances of 17 bacterial families and genera, while there were no significant changes in any of these metrics in the weight loss group. Previous research has reported differences in the gut microbiome associated with varying body compositions. More specifically, within populations of mothers, the focus has been on the impact of gestational weight gain. This is the first study to examine postpartum weight change and its association with changes in the gut microbiome, similarly, it is the first to use a Latina cohort to do so. The results support the idea that weight gain may be an important factor in reducing gut microbiome network connectivity, diversity, and changing abundances of specific microbial taxa, all measures thought to impact host health. These results suggest that weight gain dynamically alters mothers’ gut microbial communities in the first 6 months postpartum, with comparatively little change in mothers who lost weight; further research is needed to examine the health consequences of such changes.
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影响因子：
3.7
作者：
Dominianni C;Sinha R;Goedert JJ;Pei Z;Yang L;Hayes RB;Ahn J
通讯作者：
Ahn J
影响因子：
12.2
作者：
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Alderete, Tanya L.
影响因子：
17.1
作者：
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通讯作者：
Finlay, B. Brett
影响因子：
3.8
作者：
Berger, Paige K.;Plows, Jasmine F.;Goran, Michael, I
通讯作者：
Goran, Michael, I
DOI：
10.1073/pnas.1502875112
发表时间：
2015-09-01
影响因子：
11.1
作者：
DiGiulio, Daniel B.;Callahan, Benjamin J.;Relman, David A.
通讯作者：
Relman, David A.