Sex, body mass index, and dietary fiber intake influence the human gut microbiome.
Sex, body mass index, and dietary fiber intake influence the human gut microbiome.
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DOI：
10.1371/journal.pone.0124599
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Ahn J
中科院分区：
文献类型：
--
作者：
Dominianni C;Sinha R;Goedert JJ;Pei Z;Yang L;Hayes RB;Ahn J
越来越多的证据表明，人类肠道微生物组的组成在人类疾病的病因学中很重要;然而，影响肠道微生物组组成的个人因素的特征很差。动物模型指出了微生物组组成中与性别相关的差异。在这项研究中，我们调查了82名人类的性别，体重指数（BMI）和膳食纤维摄入量与肠道微生物组的关系。我们通过454 FLX技术对粪便16 S rRNA基因进行测序，然后使用QIIME管道对微生物基因组的读段进行聚类和分类。性别、BMI和纤维摄入量与总体肠道微生物组组成和特定分类丰度的关系分别通过置换MANOVA和多变量logistic回归进行评估。我们发现性别与肠道微生物组的整体组成相关（p=0.001）。女性肠道微生物组的特征是拟杆菌属丰度较低（p=0.03）。BMI（>25 kg/m2 vs. <25 kg/m2）与肠道微生物组的总体组成相关（p=0.05），这种关系在女性中很强（p=0.03），但在男性中没有（p=0.29）。来自豆类和来自水果和蔬菜的纤维分别与放线菌（p=0.006和错误发现率调整q=0.05）和梭菌（p=0.009和错误发现率调整q=0.09）的更大丰度相关。我们的研究结果表明，性别，BMI和膳食纤维有助于塑造人类的肠道微生物组。更好地理解这些关系可能对胃肠道健康和疾病预防具有重要意义。
Increasing evidence suggests that the composition of the human gut microbiome is important in the etiology of human diseases; however, the personal factors that influence the gut microbiome composition are poorly characterized. Animal models point to sex hormone-related differentials in microbiome composition. In this study, we investigated the relationship of sex, body mass index (BMI) and dietary fiber intake with the gut microbiome in 82 humans. We sequenced fecal 16S rRNA genes by 454 FLX technology, then clustered and classified the reads to microbial genomes using the QIIME pipeline. Relationships of sex, BMI, and fiber intake with overall gut microbiome composition and specific taxon abundances were assessed by permutational MANOVA and multivariate logistic regression, respectively. We found that sex was associated with the gut microbiome composition overall (p=0.001). The gut microbiome in women was characterized by a lower abundance of Bacteroidetes (p=0.03). BMI (>25 kg/m2 vs. <25 kg/m2) was associated with the gut microbiome composition overall (p=0.05), and this relationship was strong in women (p=0.03) but not in men (p=0.29). Fiber from beans and from fruits and vegetables were associated, respectively, with greater abundance of Actinobacteria (p=0.006 and false discovery rate adjusted q=0.05) and Clostridia (p=0.009 and false discovery rate adjusted q=0.09). Our findings suggest that sex, BMI, and dietary fiber contribute to shaping the gut microbiome in humans. Better understanding of these relationships may have significant implications for gastrointestinal health and disease prevention.
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DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
10.9
作者：
Bulun, Serdar E.;Chen, Dong;Moy, Irene;Brooks, David C.;Zhao, Hong
通讯作者：
Zhao, Hong
影响因子：
24.5
作者：
LAMPE, JW;FREDSTROM, SB;POTTER, JD
通讯作者：
POTTER, JD
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
29.4
作者：
GIBSON, GR;BEATTY, ER;CUMMINGS, JH
通讯作者：
CUMMINGS, JH