Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of age.
Postnatal exposure to ambient air pollutants is associated with the composition of the infant gut microbiota at 6-months of age.
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DOI：
10.1080/19490976.2022.2105096
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Alderete, Tanya L.
中科院分区：
文献类型：
--
作者：
Bailey, Maximilian J.;Holzhausen, Elizabeth A.;Morgan, Zachariah E. M.;Naik, Noopur;Shaffer, Justin P.;Liang, Donghai;Chang, Howard H.;Sarnat, Jeremy;Sun, Shan;Berger, Paige K.;Schmidt, Kelsey A.;Lurmann, Frederick;Goran, Michael, I;Alderete, Tanya L.
成人的流行病学研究表明，暴露于环境空气污染（AAP）与成人肠道微生物组的组成有关，但这些关系尚未在婴儿期进行研究。我们的目的是确定出生后6个月AAP暴露是否与来自南加州母乳研究的拉丁裔母婴配对队列（n = 103）中6个月大的婴儿肠道微生物群相关。我们估计颗粒物（PM2.5和PM10）和二氧化氮（NO2）暴露从出生到6个月的居住地址的基础上的历史。我们在6个月大时使用16S rRNA扩增子测序来表征婴儿肠道微生物群。在6个月时，肠道微生物群由拟杆菌门、厚壁菌门、变形菌门和放线菌门占主导地位。我们的研究结果表明，在调整了重要的混杂因素后，出生后AAP暴露与肠道微生物群的组成有关。例如，PM10暴露与Dialister、Dorea、Acinetobacter和Campylobacter正相关，而PM2.5与Actinomyces正相关。此外，暴露于PM10和PM2.5与Alistipes呈负相关，NO2暴露与放线菌，肠球菌，梭菌和真杆菌呈正相关。这些分类群中的几个以前与全身性炎症有关，包括Dialister和Dorea属。这项研究提供了暴露于AAP与婴儿肠道微生物群组成之间存在显著关联的第一个证据，这可能对未来婴儿的健康和发育具有重要意义。
Epidemiological studies in adults have shown that exposure to ambient air pollution (AAP) is associated with the composition of the adult gut microbiome, but these relationships have not been examined in infancy. We aimed to determine if 6-month postnatal AAP exposure was associated with the infant gut microbiota at 6 months of age in a cohort of Latino mother-infant dyads from the Southern California Mother’s Milk Study (n = 103). We estimated particulate matter (PM2.5 and PM10) and nitrogen dioxide (NO2) exposure from birth to 6-months based on residential address histories. We characterized the infant gut microbiota using 16S rRNA amplicon sequencing at 6-months of age. At 6-months, the gut microbiota was dominated by the phyla Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria. Our results show that, after adjusting for important confounders, postnatal AAP exposure was associated with the composition of the gut microbiota. As an example, PM10 exposure was positively associated with Dialister, Dorea, Acinetobacter, and Campylobacter while PM2.5 was positively associated with Actinomyces. Further, exposure to PM10 and PM2.5 was inversely associated with Alistipes and NO2 exposure was positively associated with Actinomyces, Enterococcus, Clostridium, and Eubacterium. Several of these taxa have previously been linked with systemic inflammation, including the genera Dialister and Dorea. This study provides the first evidence of significant associations between exposure to AAP and the composition of the infant gut microbiota, which may have important implications for future infant health and development.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.2
作者：
Espinosa JS;Stryker MP
通讯作者：
Stryker MP
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
DOI：
10.1007/978-1-4939-0897-4_17
发表时间：
2014-01-01
期刊：
MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE
影响因子：
--
作者：
Borre, Yuliya E.;Moloney, Rachel D.;Cryan, John F.
通讯作者：
Cryan, John F.
影响因子：
15.1
作者：
Aho VTE;Houser MC;Pereira PAB;Chang J;Rudi K;Paulin L;Hertzberg V;Auvinen P;Tansey MG;Scheperjans F
通讯作者：
Scheperjans F