Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.

Programmed ribosomal frameshifting in HIV-1 and the SARS-CoV.
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DOI:
10.1016/j.virusres.2005.10.008
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发表时间:
2006-07
期刊:
影响因子:
5
通讯作者:
Dos Ramos FJ
Dos Ramos FJ
中科院分区:
医学3区
文献类型:
--
作者:
Brierley I;Dos Ramos FJ

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核糖体移码是几种RNA病毒用于表达复制酶的基因表达机制。这篇文章的重点是移码在两个人类病原体,逆转录病毒人类免疫缺陷病毒1型(HIV-1)和冠状病毒负责严重急性呼吸综合征(SARS)。将描述HIV-1和SARS-CoV移码信号的性质,并考虑这种知识对移码模型的影响。移码在这两种病原体复制周期中的作用以及潜在的针对移码的抗病毒治疗也将被讨论。
Ribosomal frameshifting is a mechanism of gene expression used by several RNA viruses to express replicase enzymes. This article focuses on frameshifting in two human pathogens, the retrovirus human immunodeficiency virus type 1 (HIV-1) and the coronavirus responsible for severe acute respiratory syndrome (SARS). The nature of the frameshift signals of HIV-1 and the SARS–CoV will be described and the impact of this knowledge on models of frameshifting will be considered. The role of frameshifting in the replication cycle of the two pathogens and potential antiviral therapies targeting frameshifting will also be discussed.
DOI: 10.1016/0022-2836(91)90361-9
发表时间: 1991-08-20
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