Targeting disease through novel pathways of apoptosis and autophagy.
Targeting disease through novel pathways of apoptosis and autophagy.
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DOI：
10.1517/14728222.2012.719499
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发表时间：
2012-12
影响因子：
5.8
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Maiese K;Chong ZZ;Shang YC;Wang S
细胞凋亡和自噬影响机体多个系统的细胞死亡。针对这些过程的新治疗策略的开发必须解决它们在发育细胞生长和有毒细胞环境调节过程中的复杂作用。包括wnt1诱导的信号通路蛋白1 （WISP1）、磷酸肌肽3激酶（PI3K）、蛋白激酶B （Akt）、β-catenin和哺乳动物雷帕霉素靶点（mTOR）在内的新的信号通路在氧化应激过程中调控凋亡和自噬通路，影响广泛疾病实体的过程，包括阿尔茨海默病、帕金森病、心肌损伤、骨骼系统创伤、免疫系统功能障碍和癌症进展。这些信号通路的潜在生物学和临床结果的含义被提出。CCN家族成员WISP1及其与PI3K、Akt1、β-catenin和mTOR的规范和非规范无翼信号通路的密切关系为调控细胞凋亡和自噬通路提供了令人兴奋的方法，特别是在目前没有有效治疗的临床疾病中。未来的研究可以阐明这些细胞保护途径在细胞凋亡和自噬过程中的复杂作用，从而进一步成功地将这些细胞靶点转化和发展为强大和安全的临床治疗策略。
Apoptosis and autophagy impact cell death in multiple systems of the body. Development of new therapeutic strategies that target these processes must address their complex role during developmental cell growth as well as during the modulation of toxic cellular environments. Novel signaling pathways involving Wnt1-inducible signaling pathway protein 1 (WISP1), phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), β-catenin and mammalian target of rapamycin (mTOR) govern apoptotic and autophagic pathways during oxidant stress that affect the course of a broad spectrum of disease entities including Alzheimer’s disease, Parkinson’s disease, myocardial injury, skeletal system trauma, immune system dysfunction and cancer progression. Implications of potential biological and clinical outcome for these signaling pathways are presented. The CCN family member WISP1 and its intimate relationship with canonical and non-canonical wingless signaling pathways of PI3K, Akt1, β-catenin and mTOR offer an exciting approach for governing the pathways of apoptosis and autophagy especially in clinical disorders that are currently without effective treatments. Future studies that can elucidate the intricate role of these cytoprotective pathways during apoptosis and autophagy can further the successful translation and development of these cellular targets into robust and safe clinical therapeutic strategies.
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影响因子：
5.8
作者：
Chong ZZ;Shang YC;Wang S;Maiese K
通讯作者：
Maiese K
影响因子：
2.7
作者：
Cechetti, Fernanda;Worm, Paulo Valdeci;Netto, Carlos Alexandre
通讯作者：
Netto, Carlos Alexandre
影响因子：
4.8
作者：
Balan, Vitaly;Miller, Gregory S.;Tzivion, Guri
通讯作者：
Tzivion, Guri
影响因子：
15.1
作者：
Bhaskar K;Miller M;Chludzinski A;Herrup K;Zagorski M;Lamb BT
通讯作者：
Lamb BT
影响因子：
9.3
作者：
Chong ZZ;Shang YC;Maiese K
通讯作者：
Maiese K