The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans.
The mab-9 gene controls the fate of B, the major male-specific blast cell in the tail region of Caenorhabditis elegans.
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mab-9 基因控制 B 的命运，B 是秀丽隐杆线虫尾部区域主要的雄性特异性母细胞。
DOI：
10.1101/gad.3.9.1413
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发表时间：
1989
影响因子：
10.5
通讯作者：
Jonathan Hodgkin
中科院分区：
文献类型：
--
作者：
Andrew D. Chisholm;Jonathan Hodgkin
雄性秀丽隐杆线虫尾部的内部结构由四个细胞（B、Y、F和U）的后代组成，这些细胞仅在雄性中分裂。这些细胞也存在于雌雄同体，在直肠中起次要的结构作用。在这里，我们表明，基因mAb-9是两个这些男性特异性母细胞，B和F的正确发展所必需的。在突变雄性中，B和F的谱系分别类似于Y和U的谱系。这些不正常的血统导致雄性尾巴严重缺陷。我们认为，在mAb-9雄性中，B和F的身份被转换为Y和U，它们各自的前邻居。F到U转化的情况不如B到Y转化的情况强，因为F和U的野生型谱系非常相似。一些单抗-9雌雄同体由于异常直肠结构而便秘。这可能是类似的命运转变的结果。两种性别的mAb-9蠕虫稍微不协调。我们提出，四个直肠细胞的命运最初被指定为两对（B和Y，F和U），并且在两种性别中，mAb-9的功能是区分每对细胞的后部成员与其前部相邻细胞。
The internal structures of the tail of male Caenorhabditis elegans nematodes are made by the descendants of four cells (B, Y, F, and U) which divide only in males. These cells are also present in hermaphrodites, where they have minor structural roles in the rectum. Here we show that the gene mab-9 is required for the correct development of two of these male-specific blast cells, B and F. In mutant males, the lineages of B and F resemble those of Y and U, respectively. These abnormal lineages lead to grossly defective male tails. We suggest that in mab-9 males the identities of B and F are transformed into Y and U, their respective anterior neighbors. The case for the F-to-U transformation is less strong than for the B-to-Y transformation because the wild-type lineages of F and U are very similar. Some mab-9 hermaphrodites are constipated as a result of abnormal rectal structure. This may be the result of an analogous fate transformation. mab-9 worms of both sexes are slightly uncoordinated. We propose that the fates of the four rectal cells are initially specified as two pairs (B and Y, F and U) and that the function of mab-9 in both sexes is to differentiate the posterior member of each pair from its anterior neighbor.
影响秀丽隐杆线虫神经系统结构的两个基因的镶嵌分析。
影响因子：
3.3
作者：
Herman,RK
通讯作者：
Herman,RK
影响因子：
56.9
作者：
AMBROS, V;HORVITZ, HR
通讯作者：
HORVITZ, HR
unc-93(e1500)：秀丽隐杆线虫的行为突变体，定义了具有野生型无效表型的基因。
影响因子：
3.3
作者：
Greenwald,IS;Horvitz,HR
通讯作者：
Horvitz,HR