Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography.
Analysis of morphological features and vascular layers of choroid in diabetic retinopathy using spectral-domain optical coherence tomography.
复制标题
DOI：
10.1001/jamaophthalmol.2013.4321
复制
发表时间：
2013-10
影响因子：
8.1
通讯作者：
Duker, Jay S.
中科院分区：
文献类型：
--
作者：
Adhi, Mehreen;Brewer, Erika;Waheed, Nadia K.;Duker, Jay S.
糖尿病视网膜病变(DR)的特征是视网膜内微动脉瘤、毛细血管无灌注和缺血，最终导致新生血管和/或黄斑水肿。有证据表明脉络膜血管病变可能与视网膜血管损伤并存。光谱域光学相干层析成像(SD-OCT)的最新进展使脉络膜的可视化成为可能。应用SD-OCT分析糖尿病视网膜病变患者脉络膜的形态特征和脉络膜血管层数。一项横断面回顾研究确定了从2010年2月1日至2012年6月30日期间接受单线栅格扫描的DR患者和健康受试者(对照组)。分为3组：非增殖型无黄斑水肿组(9只眼)、增殖型无黄斑水肿组(10只眼)和糖尿病黄斑水肿组(14只眼)。两位独立的评分者在分析OCT图像时评估了脉络膜的形态特征和血管构筑。新英格兰眼科中心。DR组33例33眼，对照组24例24眼。糖尿病视网膜病变。脉络膜形态特征及血管分析。非增殖型DR组9只眼中8只眼(89%)、PDR组10只眼中9只眼(90%)、DME组14只眼中13只眼(93%)脉络膜巩膜界面轮廓不规则，而对照组24只眼中均为0。DR组脉络膜最厚处移位，脉络膜变薄，平均中心凹下脉络膜厚度、平均中心凹下脉络膜中脉络膜血管层和脉络膜毛细血管层厚度明显低于对照组(P<0.05)和DME组(P<0.05)。中至重度DR患者脉络膜形态特征发生改变，PDR和DME患者中心凹下脉络膜厚度、中心凹下脉络膜血管层和脉络膜毛细血管层厚度明显降低。据我们所知，这是第一次使用SD-OCT分析糖尿病视网膜病变脉络膜的形态特征和血管构筑。这些发现可能对预测DR的进展有临床意义。
Diabetic retinopathy (DR) is characterized by microaneurysms, capillary nonperfusion, and ischemia within the retina, ultimately leading to neovascularization and/or macular edema. Evidence suggests that choroidal angiopathy may coexist with retinal vascular damage. Recent advances in spectral-domain optical coherence tomography (SD-OCT) permit an efficient visualization of the choroid. To analyze the morphological features and vascular layers of the choroid in patients with DR using SD-OCT. A cross-sectional retrospective review identified patients with DR and healthy (control) subjects who underwent 1-line raster scanning from February 1, 2010, through June 30, 2012. Patients were classified into the following 3 groups: nonproliferative DR without macular edema (9 eyes), proliferative DR without macular edema (PDR) (10 eyes), and diabetic macular edema (DME) (14 eyes). Two independent raters experienced in analyzing OCT images evaluated the morphological features and vasculature of the choroid. New England Eye Center. Thirty-three eyes of 33 patients with DR and 24 eyes of 24 controls. Diabetic retinopathy. Choroidal morphological features and vasculature analysis. The choroidoscleral interface had an irregular contour in 8 of 9 eyes with nonproliferative DR (89%), 9 of 10 eyes with PDR (90%), and 13 of 14 eyes with DME (93%) compared with 0 of 24 controls. The thickest point of the choroid was displaced from under the fovea, and focal choroidal thinning was observed in eyes with DR. Mean subfoveal choroidal thickness and mean subfoveal medium choroidal vessel layer and choriocapillaris layer thickness were significantly reduced in eyes with PDR (P < .05) and DME (P < .05) compared with controls. Choroidal morphological features are altered in patients with moderate to severe DR. The subfoveal choroidal thickness and the subfoveal medium choroidal vessel layer and choriocapillaris layer thicknesses are significantly reduced in patients with PDR and DME. To our knowledge, this is the first study to analyze the morphological features and vasculature of the choroid in DR using SD-OCT. These findings may be clinically useful in predicting the progression of DR.
登录
查看更多内容
影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
Duker JS
影响因子：
17.8
作者：
Nickla, Debora L.;Wallman, Josh
通讯作者：
Wallman, Josh
DOI：
10.2147/opth.s30907
发表时间：
2012
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Ellabban AA;Tsujikawa A;Ogino K;Ooto S;Yamashiro K;Oishi A;Yoshimura N
通讯作者：
Yoshimura N
影响因子：
17.8
作者：
Kur, Joanna;Newman, Eric A.;Chan-Ling, Tailoi
通讯作者：
Chan-Ling, Tailoi
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.