Molecular genetics of attention-deficit/hyperactivity disorder: an overview.
Molecular genetics of attention-deficit/hyperactivity disorder: an overview.
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DOI：
10.1007/s00787-010-0090-z
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发表时间：
2010-03
影响因子：
6.4
通讯作者：
Coghill, David
中科院分区：
文献类型：
--
作者：
Banaschewski, Tobias;Becker, Katja;Scherag, Susann;Franke, Barbara;Coghill, David
由于注意力缺陷多动障碍（ADHD）的遗传性很高，因此遗传因素在这种疾病的发展和过程中起着重要作用。近年来，关于ADHD的候选基因的研究已大量发表，其中大部分集中在多巴胺能神经传递系统相关基因上，如DRD 4、DRD 5、DAT 1/SLC 6A 3、DBH、DDC等。与去甲肾上腺素能系统（如NET 1/SLC 6A 2、ADRA 2A、ADRA 2C）和去甲肾上腺素能系统（如5-HTT/SLC 6A 4、HTR 1B、HTR 2A、TPH 2）相关的基因也受到了相当大的关注。与神经传递和神经元可塑性相关的其他候选基因研究较少，包括SNAP 25、CHRNA 4、NMDA、BDNF、NGF、NTF 3、NTF 4/5、GDNF。这篇综述文章提供了这些候选基因研究的概述，并总结了最近发表的全基因组关联研究（GWAS）的结果。GWAS是一种相对较新的工具，能够以无假设的方式识别新的ADHD基因。虽然这些研究可以改进，需要复制，他们开始牵连的过程，如神经元迁移和细胞粘附和细胞分裂的ADHD的病因学潜在的重要性，并提出了几个新的方向，为未来的ADHD遗传学研究。
As heritability is high in attention-deficit/hyperactivity disorder (ADHD), genetic factors must play a significant role in the development and course of this disorder. In recent years a large number of studies on different candidate genes for ADHD have been published, most have focused on genes involved in the dopaminergic neurotransmission system, such as DRD4, DRD5, DAT1/SLC6A3, DBH, DDC. Genes associated with the noradrenergic (such as NET1/SLC6A2, ADRA2A, ADRA2C) and serotonergic systems (such as 5-HTT/SLC6A4, HTR1B, HTR2A, TPH2) have also received considerable interest. Additional candidate genes related to neurotransmission and neuronal plasticity that have been studied less intensively include SNAP25, CHRNA4, NMDA, BDNF, NGF, NTF3, NTF4/5, GDNF. This review article provides an overview of these candidate gene studies, and summarizes findings from recently published genome-wide association studies (GWAS). GWAS is a relatively new tool that enables the identification of new ADHD genes in a hypothesis-free manner. Although these latter studies could be improved and need to be replicated they are starting to implicate processes like neuronal migration and cell adhesion and cell division as potentially important in the aetiology of ADHD and have suggested several new directions for future ADHD genetics studies.
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DOI：
10.1002/ajmg.b.30296
发表时间：
2006-06-05
影响因子：
2.8
作者：
Banerjee, Emili;Sinha, Swagata;Nandagopal, Krishnadas
通讯作者：
Nandagopal, Krishnadas
影响因子：
17.7
作者：
Asherson, Philip;Brookes, Keeley;Faraone, Stephen V.
通讯作者：
Faraone, Stephen V.
影响因子：
11
作者：
Adams, J;Crosbie, J;Barr, CL
通讯作者：
Barr, CL
影响因子：
9.8
作者：
Arcos-Burgos, M;Castellanos, FX;Muenke, M
通讯作者：
Muenke, M
影响因子：
11
作者：
Asherson, P.;Zhou, K.;Faraone, S. V.
通讯作者：
Faraone, S. V.