Enzyme responsive self-assembled amphiphilic diblock copolymer synthesized by the combination of NMP and macromolecular azo coupling reaction
Enzyme responsive self-assembled amphiphilic diblock copolymer synthesized by the combination of NMP and macromolecular azo coupling reaction
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NMP与大分子偶氮偶联反应合成酶响应自组装两亲性二嵌段共聚物
DOI：
10.1016/j.eurpolymj.2016.09.030
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发表时间：
2016-11
影响因子：
6
通讯作者：
He Yaning
中科院分区：
文献类型：
--
作者：
Wang Jilei;Li Shang;Wu Bing;He Yaning
通过大分子偶氮偶联反应和氮氧自由基聚合（NMP）相结合的方法合成了含偶氮苯的两亲性嵌段共聚物。在该策略中，在大分子偶氮偶联反应之后，偶氮苯连接将自然地建立在两亲性二嵌段共聚物的共聚物连接处。这种偶氮苯连接的共聚物在选定的溶剂中的自组装可以产生均匀的自组装聚集体。在酶偶氮还原酶和辅酶NADPH的存在下，两亲性二嵌段共聚物链将通过偶氮苯键的裂解而断裂，这将导致自组装聚集体的破坏。紫外-可见吸收光谱的测量表明，释放尼罗红，疏水染料，封装的自组装聚集体。因此，具有偶氮苯键的两亲性二嵌段共聚物可以潜在地应用于制造用于结肠特异性递送目的应用的纳米载体。
Amphiphilic diblock copolymer with an azobenzene linkage has been synthesized by the combination of macromolecular azo coupling reaction and nitroxide-mediated radical polymerization (NMP). In this strategy, an azobenzene linkage would naturally establish at the copolymer junction of the amphiphilic diblock copolymer after the macromolecular azo coupling reaction. Self-assembly of this azobenzene linked copolymer in selected solvents can result uniform self-assembly aggregates. In the presence of enzyme azoreductase and coenzyme NADPH, the amphiphilic diblock copolymer chain will be broken by the cleavage of the azobenzene linkage, which will lead to the disruption of the self-assembly aggregates. UV–vis absorption spectra measurements indicated the release of Nile red, a hydrophobic dye, encapsulated by the self-assembly aggregates. Thus, the amphiphilic diblock copolymer with azobenzene linkage can potentially be applied for the fabrication of nanocarriers for colon-specific delivery purposes applications.
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影响因子：
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通讯作者：
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