Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis.
Validation of patient determined disease steps (PDDS) scale scores in persons with multiple sclerosis.
复制标题
DOI：
10.1186/1471-2377-13-37
复制
发表时间：
2013-04-25
期刊：
影响因子：
2.6
通讯作者：
Cadavid D
中科院分区：
文献类型：
--
作者：
Learmonth YC;Motl RW;Sandroff BM;Pula JH;Cadavid D
患者决定的疾病步骤（PDDS）是一个有前途的患者报告的结果（PRO）的残疾多发性硬化症（MS）。迄今为止，有有限的证据PDDS评分的有效性，尽管其良好的概念发展和广泛纳入MS研究。本研究基于（1）与扩展残疾状态量表（EDSS）评分的相关性和（2）PDDS和EDSS评分与功能系统（FS）评分以及非卧床和其他结局之间的相关模式，检查了PDDS的有效性。96名MS患者提供了人口统计学/临床信息，完成了PDDS和其他PRO，包括多发性硬化症步行量表-12（MSWS-12），并接受了神经系统检查，以生成FS和EDSS评分。参与者完成了认知评估，包括6分钟步行（6 MW），并在7天的清醒时间内佩戴加速度计。EDSS和PDDS评分之间存在很强的相关性（ρ = 0.783）。PDDS和EDSS评分与Pyramidal显著相关，（分别为ρ = .578和ρ = .647）和小脑（分别为ρ = .501和ρ = .528）FS评分以及6 MW距离（分别为ρ = .704和ρ = .805）、MSWS-12评分（分别为ρ = .801和ρ = .729）和加速度计步数/天（分别为ρ = -.740和ρ = -.717）。这项研究提供了新的证据，支持PDDS作为MS残疾的有效PRO。
The Patient Determined Disease Steps (PDDS) is a promising patient-reported outcome (PRO) of disability in multiple sclerosis (MS). To date, there is limited evidence regarding the validity of PDDS scores, despite its sound conceptual development and broad inclusion in MS research. This study examined the validity of the PDDS based on (1) the association with Expanded Disability Status Scale (EDSS) scores and (2) the pattern of associations between PDDS and EDSS scores with Functional System (FS) scores as well as ambulatory and other outcomes. 96 persons with MS provided demographic/clinical information, completed the PDDS and other PROs including the Multiple Sclerosis Walking Scale-12 (MSWS-12), and underwent a neurological examination for generating FS and EDSS scores. Participants completed assessments of cognition, ambulation including the 6-minute walk (6 MW), and wore an accelerometer during waking hours over seven days. There was a strong correlation between EDSS and PDDS scores (ρ = .783). PDDS and EDSS scores were strongly correlated with Pyramidal (ρ = .578 &ρ = .647, respectively) and Cerebellar (ρ = .501 &ρ = .528, respectively) FS scores as well as 6 MW distance (ρ = .704 &ρ = .805, respectively), MSWS-12 scores (ρ = .801 &ρ = .729, respectively), and accelerometer steps/day (ρ = -.740 &ρ = -.717, respectively). This study provides novel evidence supporting the PDDS as valid PRO of disability in MS.
登录
查看更多内容
影响因子：
9.9
作者：
Marrie, R. A.;Horwitz, R.;Vollmer, T.
通讯作者：
Vollmer, T.
影响因子：
9.9
作者：
Marrie, R. A.;Rudick, R.;Vollmer, T.
通讯作者：
Vollmer, T.
影响因子：
9.9
作者：
Hobart, JC;Riazi, A;Thompson, AJ
通讯作者：
Thompson, AJ
影响因子：
7.4
作者：
Hadjimichael, Olympia;Kerns, Robert D.;Vollmer, Timothy
通讯作者：
Vollmer, Timothy
影响因子：
6
作者：
Julian, Laura J.;Vella, Lea;Mohr, David C.
通讯作者：
Mohr, David C.