Objectively Measured Physical Activity and Symptoms Change in Knee Osteoarthritis.
Objectively Measured Physical Activity and Symptoms Change in Knee Osteoarthritis.
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DOI：
10.1016/j.amjmed.2015.12.029
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Lapane KL
中科院分区：
文献类型：
--
作者：
Liu SH;Driban JB;Eaton CB;McAlindon TE;Harrold LR;Lapane KL
量化膝关节骨关节炎患者通过加速度计测量的日常身体活动与1年症状变化之间的相关性。骨关节炎倡议（OAI）的参与者在48个月访视时接受膝关节X线片检查，并使用GT 1 M ActiGraph单轴加速度计评估体力活动。计算体力活动，并将其分类为轻度和中度至剧烈活动的平均每日分钟数的三分位数。结局为采用西安大略和麦克马斯特大学（WOMAC）量表测量的1年症状变化，包括疼痛、僵硬和身体功能。调整后的多变量线性模型估计了轻度或中度至剧烈体力活动的三分位数与膝关节症状变化之间的关系。在1，059名参与者（55%为女性，平均年龄66±9岁）中，轻度活动时间延长与身体功能下降趋势相关（P = 0.01）。每天中到剧烈活动的时间增加也与身体功能下降（P = 0.01）和疼痛增加（P = 0.08）相关。这些症状的平均变化均未达到最低重要临床差异。然而，在K-L 4级骨关节炎患者中，每天进行这两种活动的时间越长，症状恶化的可能性越高。客观测量的日常活动与社区居住的膝关节骨关节炎成年人1年症状改善无关。在晚期疾病（K-L 4级）患者中，每日体力活动分钟数增加与症状恶化相关。如何最好地实施运动方案的人与先进的膝关节骨关节炎，以减少对症状的有害影响，需要探讨。
To quantify the association between daily physical activity measured by accelerometer and 1-year changes in symptoms among people with knee osteoarthritis. Participants from the Osteoarthritis Initiative (OAI) had knee radiographs and physical activity assessed using GT1M ActiGraph uniaxial accelerometers at the 48 months visit. Physical activity was calculated and categorized as tertiles of average daily minutes in light and moderate-to-vigorous activity. Outcomes were 1-year change in symptoms measured by Western Ontario and McMaster Universities (WOMAC) scales including pain, stiffness, and physical function. Adjusted multivariable linear models estimated the relationship between tertiles of light or moderate-to-vigorous physical activity and changes in knee symptoms. Among 1,059 participants (55% women, mean age 66±9 years), greater time in light activity was associated with a trend towards declined physical function (P = 0.01). Greater time in daily moderate-to-vigorous activity was also associated with declined physical function (P = 0.01) and increased pain (P = 0.08). None of these average changes in symptoms reached minimally important clinical differences. However, greater daily time in both activities was associated with higher probability of worsening symptoms among persons with K-L grade 4 osteoarthritis. Objectively measured daily activity was not associated with 1-year symptom improvements among community dwelling adults with knee osteoarthritis. In those with advanced disease (K-L grade 4), greater daily minutes in physical activity were associated with worsening symptoms. How best to implement exercise regimens in persons with advanced knee osteoarthritis to reduce the deleterious impact on symptoms needs to be explored.
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影响因子：
37.8
作者：
Jensen MD;Ryan DH;Apovian CM;Ard JD;Comuzzie AG;Donato KA;Hu FB;Hubbard VS;Jakicic JM;Kushner RF;Loria CM;Millen BE;Nonas CA;Pi-Sunyer FX;Stevens J;Stevens VJ;Wadden TA;Wolfe BM;Yanovski SZ;Jordan HS;Kendall KA;Lux LJ;Mentor-Marcel R;Morgan LC;Trisolini MG;Wnek J;Anderson JL;Halperin JL;Albert NM;Bozkurt B;Brindis RG;Curtis LH;DeMets D;Hochman JS;Kovacs RJ;Ohman EM;Pressler SJ;Sellke FW;Shen WK;Smith SC Jr;Tomaselli GF;American College of Cardiology/American Heart Association Task Force on Practice Guidelines;Obesity Society
通讯作者：
Obesity Society
影响因子：
4.7
作者：
Christensen R;Henriksen M;Leeds AR;Gudbergsen H;Christensen P;Sørensen TJ;Bartels EM;Riecke BF;Aaboe J;Frederiksen R;Boesen M;Lohmander LS;Astrup A;Bliddal H
通讯作者：
Bliddal H
影响因子：
13.3
作者：
Juhl, C.;Christensen, R.;Lund, H.
通讯作者：
Lund, H.
影响因子：
--
作者：
Dunlop, Dorothy D.;Song, Jing;Semanik, Pamela A.;Sharma, Leena;Chang, Rowland W.
通讯作者：
Chang, Rowland W.
影响因子：
12.7
作者：
Pate, RR;Heath, GW;Trost, SG
通讯作者：
Trost, SG