Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections.
Autoantibodies during infectious diseases: Lessons from malaria applied to COVID-19 and other infections.
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DOI：
10.3389/fimmu.2022.938011
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
自身免疫是许多全球相关感染中报告的常见现象，包括疟疾和COVID-19。这些和其他高度炎症性疾病与自身抗体的存在有关。这些自身抗体在感染过程中发挥的作用一直是一个新兴的感兴趣的话题。大量研究报告了一系列针对细胞抗原（如dsDNA和脂质）以及免疫分子（如细胞因子）的自身抗体，在疟疾，COVID-19和其他感染期间，强调了自身免疫在感染期间的重要性。在疟疾和COVID-19期间，自身抗体的存在与相关的病理学相关，如疟疾性贫血和严重的COVID-19。此外，在这两种疾病中均观察到高水平的非典型/自身免疫B细胞（ABC和非典型B细胞）。系统性红斑狼疮（SLE）和其他自身免疫性疾病中自身免疫性B细胞、年龄相关性B细胞和非典型B细胞的文献越来越多，最近已经确定了可以解释感染期间自身抗体发展的机制和细胞靶点。这些新发现建立了感染期间的免疫反应与自身免疫性疾病之间的联系，突出了共同的机制见解。在这篇综述中，我们专注于疟疾和其他传染病过程中自身抗体产生的最新证据及其潜在的病理作用，探索可能解释感染过程中自身免疫发展的可能机制。
Autoimmunity is a common phenomenon reported in many globally relevant infections, including malaria and COVID-19. These and other highly inflammatory diseases have been associated with the presence of autoantibodies. The role that these autoantibodies play during infection has been an emerging topic of interest. The vast numbers of studies reporting a range of autoantibodies targeting cellular antigens, such as dsDNA and lipids, but also immune molecules, such as cytokines, during malaria, COVID-19 and other infections, underscore the importance that autoimmunity can play during infection. During both malaria and COVID-19, the presence of autoantibodies has been correlated with associated pathologies such as malarial anemia and severe COVID-19. Additionally, high levels of Atypical/Autoimmune B cells (ABCs and atypical B cells) have been observed in both diseases. The growing literature of autoimmune B cells, age-associated B cells and atypical B cells in Systemic Lupus erythematosus (SLE) and other autoimmune disorders has identified recent mechanistic and cellular targets that could explain the development of autoantibodies during infection. These new findings establish a link between immune responses during infection and autoimmune disorders, highlighting shared mechanistic insights. In this review, we focus on the recent evidence of autoantibody generation during malaria and other infectious diseases and their potential pathological role, exploring possible mechanisms that may explain the development of autoimmunity during infections.
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DOI：
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期刊：
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DOI：
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发表时间：
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影响因子：
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