Frontal-thalamic circuits associated with language.

Frontal-thalamic circuits associated with language.
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DOI:
10.1016/j.bandl.2012.10.001
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发表时间:
2013-07
期刊:
影响因子:
2.5
通讯作者:
Zikopoulos, Basilis
Zikopoulos, Basilis
中科院分区:
心理学3区
文献类型:
--
作者:
Barbas, Helen;Garcia-Cabezas, Miguel Angel;Zikopoulos, Basilis

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与语言相关的丘脑核团包括腹外侧核、腹前核、板层内核和背内侧核,形成一个中枢,专门接收基底节和小脑的输出,并通过两个平行回路与额叶(运动前和前额前)皮质相连:一条丘脑通路主要针对额叶中部皮质层,另一条通路广泛支配皮质第一层,准备招募其他皮质和丘脑核团进行复杂的认知操作。返回丘脑的额叶通路来自皮质第6层和第5层。通过这个整合的丘脑-皮质系统的信息由抑制性丘脑网状核门控,并受多巴胺的调节,这代表了灵长类的一种专门化。丘脑不同的核团与基底节、小脑以及与语言相关的特定背外侧前额叶和前运动皮质之间的复杂对话,表明在人类言语产生认知操作的复杂但似乎毫不费力的顺序转换中发挥了协同作用。
Thalamic nuclei associated with language including the ventral lateral, ventral anterior, intralaminar and mediodorsal form a hub that uniquely receives the output of the basal ganglia and cerebellum, and is connected with frontal (premotor and prefrontal) cortices through two parallel circuits: a thalamic pathway targets the middle frontal cortical layers focally, and the other innervates widely cortical layer 1, poised to recruit other cortices and thalamic nuclei for complex cognitive operations. Return frontal pathways to the thalamus originate from cortical layers 6 and 5. Information through this integrated thalamo-cortical system is gated by the inhibitory thalamic reticular nucleus and modulated by dopamine, representing a specialization in primates. The intricate dialogue of distinct thalamic nuclei with the basal ganglia, cerebellum, and specific dorsolateral prefrontal and premotor cortices associated with language, suggests synergistic roles in the complex but seemingly effortless sequential transformation of cognitive operations for speech production in humans.
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