Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications.
Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: epidemiology, characteristics and public health implications.
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DOI：
10.1016/j.jhin.2016.10.008
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发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Kim MS
中科院分区：
文献类型：
--
作者：
Kim KH;Tandi TE;Choi JW;Moon JM;Kim MS
自2015年5月20日韩国报告首例中东呼吸综合征冠状病毒（MERS-CoV）病例以来，已有186例确诊病例，38例死亡和16，752例疑似病例。此前发表的关于韩国MERS疫情的研究仅限于早期阶段，当时几乎没有数据。现在疫情已经结束，尽管是非正式的，但更全面的审查是适当的。数据是通过卫生福利部（MOHW）和韩国疾病控制和预防中心的MERS门户网站、卫生福利部的新闻稿以及韩国医学会MERS政策委员会的报告获得的。分析病例的一般特征、暴露源、时间轴和感染发生。对38例死亡病例的性别、年龄和基础疾病进行了分析。从感染其他28人的指示病例开始，进行了深入分析。平均年龄为55岁，略高于全球平均年龄50岁。与大多数其他国家一样，受影响的男子多于妇女。病死率为19.9%，低于全球病死率38.7%和沙特阿拉伯病死率36.5%。总共有184名患者在医院感染，没有社区获得性感染。主要的基础疾病是呼吸系统疾病、癌症和高血压。此次疫情的主要原因是诊断晚、“超级传播者”隔离失败、家庭护理和探视、患者不披露、韩国政府沟通不畅、医院感染管理不足以及“医生购物”。这次疫情完全是医院感染，主要是由于感染管理和政策失败，而不是生物医学因素。
Since the first case of Middle East respiratory syndrome coronavirus (MERS-CoV) in South Korea was reported on 20th May 2015, there have been 186 confirmed cases, 38 deaths and 16,752 suspected cases. Previously published research on South Korea's MERS outbreak was limited to the early stages, when few data were available. Now that the outbreak has ended, albeit unofficially, a more comprehensive review is appropriate. Data were obtained through the MERS portal by the Ministry for Health and Welfare (MOHW) and Korea Centres for Disease Control and Prevention, press releases by MOHW, and reports by the MERS Policy Committee of the Korean Medical Association. Cases were analysed for general characteristics, exposure source, timeline and infection generation. Sex, age and underlying diseases were analysed for the 38 deaths. Beginning with the index case that infected 28 others, an in-depth analysis was conducted. The average age was 55 years, which was a little higher than the global average of 50 years. As in most other countries, more men than women were affected. The case fatality rate was 19.9%, which was lower than the global rate of 38.7% and the rate in Saudi Arabia (36.5%). In total, 184 patients were infected nosocomially and there were no community-acquired infections. The main underlying diseases were respiratory diseases, cancer and hypertension. The main contributors to the outbreak were late diagnosis, quarantine failure of ‘super spreaders’, familial care-giving and visiting, non-disclosure by patients, poor communication by the South Korean Government, inadequate hospital infection management, and ‘doctor shopping’. The outbreak was entirely nosocomial, and was largely attributable to infection management and policy failures, rather than biomedical factors.
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