Bone marrow stem cells and liver regeneration.
Bone marrow stem cells and liver regeneration.
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DOI：
10.1016/j.exphem.2010.04.007
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发表时间：
2010-07
影响因子：
2.6
通讯作者：
Porada, Christopher D.
中科院分区：
文献类型：
--
作者：
Almeida-Porada, Graca;Zanjani, Esmail D.;Porada, Christopher D.
开发新的方法来治疗肝病患者，可以消除肝移植的需要是势在必行的。使用细胞疗法作为重新填充肝脏的手段与整个器官移植相比具有几个优点，因为它侵入性较小，免疫原性较低，并且在某些情况下允许使用自体来源的细胞。理想的肝再生干细胞/祖细胞需要具有以下特征，例如可获得性和易于分离，体外扩增的能力，确保足够数量的细胞，对病毒载体转导/遗传重组修饰的敏感性，纠正任何潜在的遗传缺陷，以及移植后恢复肝功能的能力。骨髓来源的干细胞，如造血干细胞、间充质干细胞和内皮祖细胞具有这些特征中的一些或大部分，使它们成为肝脏再生疗法的理想候选者。在这里，我们将总结这些干细胞群中的每一个产生功能性肝脏元素的能力，这些元素可以介导肝损伤/疾病患者的修复。
The development of new approaches to treat patients with hepatic diseases that can eliminate the need for liver transplantation is imperative. The use of cell therapy as a means of repopulating the liver has several advantages over whole organ transplantation, since it would be less invasive, less immunogenic, and would allow the use, in some instances, of autologous-derived cells. Stem/progenitor cells that would be ideal for liver repopulation would need to have characteristics such as availability and ease of isolation, the ability to be expanded in vitro, ensuring adequate numbers of cells, susceptibility to modification by viral vector transduction/genetic recombination, to correct any underlying genetic defects, and the ability of restoring liver function following transplantation. Bone marrow-derived stem cells such as Hematopoietic, Mesenchymal and Endothelial Progenitor cells possess some or most of these characteristics, making them ideal candidates for liver regenerative therapies. Here, we will summarize the ability of each of these stem cell populations to give rise to functional hepatic elements which could mediate repair in patients with liver damage/disease.
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影响因子：
2.8
作者：
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通讯作者：
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