Progenitors in prostate development and disease.
Progenitors in prostate development and disease.
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DOI：
10.1016/j.ydbio.2020.11.012
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发表时间：
2021-05
影响因子：
2.7
通讯作者：
Strand DW
中科院分区：
文献类型：
--
作者：
Joseph DB;Turco AE;Vezina CM;Strand DW
前列腺通过胚胎和出生后阶段发生的上皮出芽和分支过程发育。成年前列腺显示出显著的再生能力，具有在多个去势和雄激素给药周期中再生至其原始大小的能力。这种受控再生的能力促使人们在良性前列腺增生（BPH）和前列腺癌（PCa）中寻找雄激素非依赖性上皮祖细胞。前列腺增生被假设为导管分支的重新觉醒，导致新的近端腺体的形成，而老年男性的雄激素水平正在下降。晚期前列腺癌可以通过雄激素剥夺来减缓，但最终会出现耐药性，这表明存在雄激素非依赖性祖细胞。最近的研究表明，在前列腺近端区域存在多种去势不敏感上皮细胞类型，但并非所有上皮细胞都在前列腺发育或再生过程中充当祖细胞。这篇综述强调了最近的细胞和解剖学研究如何改变我们对前列腺祖细胞身份的看法。
The prostate develops by epithelial budding and branching processes that occur during fetal and postnatal stages. The adult prostate demonstrates remarkable regenerative capacity, with the ability to regrow to its original size over multiple cycles of castration and androgen administration. This capacity for controlled regeneration prompted the search for an androgen-independent epithelial progenitor in benign prostatic hyperplasia (BPH) and prostate cancer (PCa). BPH is hypothesized to be a reawakening of ductal branching, resulting in the formation of new proximal glands, all while androgen levels are decreasing in the aging male. Advanced prostate cancer can be slowed with androgen deprivation, but resistance eventually occurs, suggesting the existence of an androgen-independent progenitor. Recent studies indicate that there are multiple castration-insensitive epithelial cell types in the proximal area of the prostate, but not all act as progenitors during prostate development or regeneration. This review highlights how recent cellular and anatomical studies are changing our perspective on the identity of the prostate progenitor.
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DOI：
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发表时间：
2004-09-01
影响因子：
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