Brown fat in humans: consensus points and experimental guidelines.

Brown fat in humans: consensus points and experimental guidelines.
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DOI:
10.1016/j.cmet.2014.07.025
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发表时间:
2014-09-02
期刊:
影响因子:
29
通讯作者:
Hu HH
Hu HH
中科院分区:
生物学1区
文献类型:
--
作者:
Cypess AM;Haft CR;Laughlin MR;Hu HH

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作为当前全球努力了解人类BAT(hBAT)的生理学以及其产热活性是否可以被操纵以治疗肥胖的一部分,2014年2月25日至26日在美国国立卫生研究院召开了研讨会“探索棕色脂肪在人类中的作用”。发言和讨论表明,hBAT及其生理作用非常复杂,需要进行研究,以了解hBAT对产热和体重调节以外的健康影响,并确定其与葡萄糖稳态、恶病质、身体活动、骨结构、睡眠和昼夜节律等核心生理过程的相互作用。
As part of a current worldwide effort to understand the physiology of human BAT (hBAT) and whether its thermogenic activity can be manipulated to treat obesity, a workshop “Exploring the Roles of Brown Fat in Humans” was convened at the National Institutes of Health on February 25–26, 2014. Presentations and discussion indicated that hBAT and its physiological roles are highly complex and research is needed to understand the health impact of hBAT beyond thermogenesis and body weight regulation, and to define its interactions with core physiological processes like glucose homeostasis, cachexia, physical activity, bone structure, sleep and circadian rhythms.
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