Aspirin for the primary prevention of skin cancer: A meta-analysis.
Aspirin for the primary prevention of skin cancer: A meta-analysis.
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DOI：
10.3892/ol.2015.2853
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发表时间：
2015-03
期刊：
影响因子：
2.9
通讯作者：
Li AM
中科院分区：
文献类型：
--
作者：
Zhu Y;Cheng Y;Luo RC;Li AM
皮肤癌是世界上最常见的癌症之一。有三种主要的皮肤癌类型：基底细胞癌、鳞状细胞癌和恶性黑色素瘤。皮肤癌的一般危险因素包括白皙的皮肤、晒黑和晒伤的历史、皮肤癌的家族史、暴露于紫外线和大量的痣。近年来，皮肤癌的发病率在美国有所增加。阿司匹林的摄入与化学保护作用有关，可以防止许多类型的癌症的发展。然而，阿司匹林的摄入是否可以降低皮肤癌的发生风险尚不清楚。目前对现有人体研究的荟萃分析旨在评估阿司匹林暴露与皮肤癌风险之间的关联。通过检索MEDLINE（Pubmed）、BIOSIS、EMBASE、科克伦图书馆和中国国家知识基础设施，确定了2013年3月之前所有可用的关于阿司匹林摄入用于皮肤癌一级预防的人体观察性研究。所有研究的异质性和发表偏倚均采用Cochran's Q和I2统计量进行评价，随后采用随机效应模型（如适用）进行评价。通过比值比（OR）和95%置信区间（CI）分析汇总数据。从11篇出版物中共选择了8项病例对照和5项前瞻性队列研究进行分析。这些研究中没有证据表明存在发表偏倚。汇总数据的统计分析表明，每日剂量为50-400 mg的阿司匹林与皮肤癌风险降低显著相关（OR，0.94; 95% CI，0.90-0.99; P=0.02）。分层分析表明，持续摄入低剂量阿司匹林（≤150 mg）可降低发生皮肤癌的风险（OR，0.95; CI，0.90-0.99; P=0.15），阿司匹林摄入与非黑色素瘤皮肤癌风险降低显著相关（OR，0.97; CI，0.95-0.99; P=0.22）。总的来说，这些发现表明阿司匹林的摄入与患皮肤癌的风险降低有关。然而，需要更多设计良好的随机对照试验来衡量阿司匹林摄入的影响，以证实这一点。
Skin cancer is one of the most common cancers worldwide. There are three major skin cancer types: basal cell carcinoma, squamous cell carcinoma and malignant melanoma. General risk factors for skin cancer include fair skin, a history of tanning and sunburn, family history of skin cancer, exposure to ultraviolet rays and a large number of moles. The incidence of skin cancer has increased in the USA in recent years. Aspirin intake is associated with chemoprotection against the development of a number of types of cancer. However, whether aspirin intake can reduce the risk of development of skin cancer is unclear. The present meta-analysis of available human studies is aimed at evaluating the association between aspirin exposure and the risk of skin cancer. All available human observational studies on aspirin intake for the primary prevention of skin cancer were identified by searching MEDLINE (Pubmed), BIOSIS, EMBASE, Cochrane Library and China National Knowledge Infrastructure prior to March 2013. The heterogeneity and publication bias of all studies were evaluated using Cochran’s Q and I2 statistics, followed by a random-effect model where applicable. The pooled data were analyzed by odds ratios (ORs) and 95% confidence intervals (CIs). A total of eight case-control and five prospective cohort studies from 11 publications were selected for this analysis. There was no evidence of publication bias in these studies. Statistical analyses of the pooled data demonstrated that that a daily dose of 50–400 mg aspirin was significantly associated with a reduced risk of skin cancers (OR, 0.94; 95% CI, 0.90–0.99; P=0.02). Stratification analysis indicated that the continual intake of low dose aspirin (≤150 mg) reduced the risk of developing skin cancer (OR, 0.95; CI, 0.90–0.99; P=0.15) and that aspirin intake was significantly associated with a reduced risk of non-melanoma skin cancers (OR, 0.97; CI, 0.95–0.99; P=0.22). Overall, these findings indicated that aspirin intake was associated with a reduced risk of developing skin cancer. However, more well-designed randomized controlled trials to measure the effects of aspirin intake are required to confirm this.
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影响因子：
168.9
作者：
Burn, John;Gerdes, Anne-Marie;Macrae, Finlay;Mecklin, Jukka-Pekka;Moeslein, Gabriela;Olschwang, Sylviane;Eccles, Diane;Evans, D. Gareth;Maher, Eamonn R.;Bertario, Lucio;Bisgaard, Marie-Luise;Dunlop, Malcolm G.;Ho, Judy W. C.;Hodgson, Shirley V.;Lindblom, Annika;Lubinski, Jan;Morrison, Patrick J.;Murday, Victoria;Ramesar, Raj;Side, Lucy;Scott, Rodney J.;Thomas, Huw J. W.;Vasen, Hans F.;Barker, Gail;Crawford, Gillian;Elliott, Faye;Movahedi, Mohammad;Pylvanainen, Kirsi;Wijnen, Juul T.;Fodde, Riccardo;Lynch, Henry T.;Mathers, John C.;Bishop, D. Timothy
通讯作者：
Bishop, D. Timothy
影响因子：
2.3
作者：
Jeter, J. M.;Han, J.;Martinez, M. E.;Alberts, D. S.;Qureshi, A. A.;Feskanich, D.
通讯作者：
Feskanich, D.
影响因子：
4.7
作者：
Buckman, SY;Gresham, A;Pentland, AP
通讯作者：
Pentland, AP
影响因子：
6.2
作者：
Johannesdottir, Sigrun Alba;Chang, Ellen T.;Sorensen, Henrik Toft
通讯作者：
Sorensen, Henrik Toft
影响因子：
120.7
作者：
Christenson, LJ;Borrowman, TA;Roenigk, RK
通讯作者：
Roenigk, RK