Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain.
Prenatal mild ventriculomegaly predicts abnormal development of the neonatal brain.
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DOI：
10.1016/j.biopsych.2008.07.031
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发表时间：
2008-12-15
影响因子：
10.6
通讯作者：
Gerig, Guido
中科院分区：
文献类型：
--
作者：
Gilmore, John H.;Smith, Lauren C.;Wolfe, Honor M.;Hertzberg, Barbara S.;Smith, J. Keith;Chescheir, Nancy C.;Evans, Dianne D.;Kang, Chaeryon;Hamer, Robert M.;Lin, Weili;Gerig, Guido
关键词：
许多精神和神经发育障碍与侧脑室轻度扩大有关，被认为起源于产前大脑发育。关于侧脑室的发育以及出生前侧脑室扩大与出生后脑发育的关系还知之甚少。我们对34名产前超声诊断为孤立性轻度脑室扩大（MVM，侧脑室心房宽度≥ 1.0 cm）的儿童和34名年龄和性别匹配的产前脑室大小正常的对照组进行了新生儿MRI检查。评估侧脑室和皮质灰质和白色物质体积。应用定量纤维束成像技术测定胼胝体和皮质脊髓白色物质束的各向异性分数（FA）和平均扩散率（MD）。出生前MVM的新生儿侧脑室体积明显大于对照组（286.4%; p < 0.0001）。与对照组相比，MVM新生儿的颅内体积（ICV; 7.1%，p = 0.0063）和皮质灰质体积（10.9%，p = 0.0004）也显著更大。DTI纤维束成像显示胼胝体和皮质脊髓束的MD明显更大，而几个白色束区域的FA明显更小。出生前侧脑室增大与出生后侧脑室增大、灰质体积增大以及白色物质成熟延迟或异常有关。这表明，产前脑室体积是大脑皮层发育改变的早期结构标志，并可能是与脑室扩大相关的神经精神疾病的风险标志。
Many psychiatric and neurodevelopmental disorders are associated with mild enlargement of the lateral ventricles thought to have origins in prenatal brain development. Little is known about development of the lateral ventricles and the relationship of prenatal lateral ventricle enlargement with postnatal brain development. We performed a neonatal MRI on 34 children with isolated mild ventriculomegaly (MVM, width of the atrium of the lateral ventricle ≥ 1.0 cm) on prenatal ultrasound and 34 age and gender matched controls with normal prenatal ventricle size. Lateral ventricle and cortical gray and white matter volumes were assessed. Fractional anisotropy (FA) and mean diffusivity (MD) in corpus callosum and cortico-spinal white matter tracts were determined obtained using quantitative tractography. Neonates with prenatal MVM had significantly larger lateral ventricle volumes than matched controls (286.4%; p < 0.0001). Neonates with MVM also had significantly larger intracranial volumes (ICV; 7.1%, p = 0.0063) and cortical gray matter volumes (10.9%, p = 0.0004) compared to controls. DTI tractography revealed a significantly greater MD in the corpus callosum and cortico-spinal tracts, while FA was significantly smaller in several white matter tract regions. Prenatal enlargement of the lateral ventricle is associated with enlargement of the lateral ventricles after birth, as well as greater gray matter volumes and delayed or abnormal maturation of white matter. It is suggested that prenatal ventricle volume is an early structural marker of altered development of the cerebral cortex and may be marker of risk for neuropsychiatric disorders associated with ventricle enlargement.
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影响因子：
4.5
作者：
Gilmore, JH;van Tol, JJ;Chescheir, NC
通讯作者：
Chescheir, NC
影响因子：
7.2
作者：
Bloom, SL;Bloom, DD;Twickler, DM
通讯作者：
Twickler, DM
影响因子：
2.3
作者：
Falip, Celine;Blanc, Nathalie;Garel, Catherine
通讯作者：
Garel, Catherine
影响因子：
19.7
作者：
FARRELL, TA;HERTZBERG, BS;PAINE, SS
通讯作者：
PAINE, SS
影响因子：
14.5
作者：
Hermann, Bruce;Jones, Jana;Seidenberg, Michael
通讯作者：
Seidenberg, Michael