Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder.
Autism symptoms in anorexia nervosa: a comparative study with females with autism spectrum disorder.
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DOI：
10.1186/s13229-021-00455-5
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发表时间：
2021-06-30
期刊：
影响因子：
6.2
通讯作者：
Tchanturia K
中科院分区：
文献类型：
--
作者：
Kerr-Gaffney J;Hayward H;Jones EJH;Halls D;Murphy D;Tchanturia K
最近的研究表明自闭症谱系障碍（ASD）和神经性厌食症（AN）之间存在联系。AN患者在ASD症状的测量上表现出较高的分数，相对于没有AN的个体，然而，目前还没有研究直接比较AN女性与ASD女性。本研究的目的是检查在AN的急性期和恢复期的年轻女性，ASD女性和通常发展中的对照组（TD）的ASD症状的概况，包括自我报告和临床访谈措施。包括四组年龄在12-30岁的参与者（n = 218）：AN，恢复的AN（REC），ASD和TD。社会反应量表，第2版（SRS-2），10项自闭症商（AQ-10），和自闭症诊断观察表，第2版（ADOS-2）的组间差异进行了检查。为了探索与AN和ASD相关的特定症状特征的相似性和差异，还在AN、REC和ASD中检查了ADOS-2上的单个项目认可。在所有指标中，ASD女性得分最高，TD最低。一般来说，患有AN和REC的个体表现出中间水平的ASD症状，得分介于其他两组之间。然而，AN和ASD没有不同的限制利益和重复行为分量表。ADOS-2项目“社会反应的质量”充分区分ASD和非ASD参与者。没有为AN/REC参与者提供ASD的完整诊断评估，也没有在ASD组中评估进食障碍。因此，组间可能存在一些诊断重叠。横截面设计是另一个限制。结果表明，AN和ASD的自我报告和临床访谈指标得分相似。然而，个体ADOS-2项目分析也显示了微妙的差异，特别是在互惠的社会互动。ASD症状可能是AN的状态和特征特征的组合。在线版本包含补充材料，可通过10.1186/s13229-021-00455-5获得。
Recent research suggests a link between autism spectrum disorder (ASD) and anorexia nervosa (AN). Individuals with AN show high scores on measures of ASD symptoms, relative to individuals without AN, however, there are currently no studies directly comparing women with AN to women with ASD. The aim of the current study was to examine profiles of ASD symptoms in young women in the acute and recovered stages of AN, women with ASD, and typically developing controls (TD), on both self-report and clinical interview measures. Four groups of participants aged 12–30 years were included (n = 218): AN, recovered AN (REC), ASD, and TD. Group differences on the Social Responsiveness Scale, 2nd edition (SRS-2), 10-item Autism Quotient (AQ-10), and the Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) were examined. To explore similarities and differences in specific symptom profiles associated with AN and ASD, individual item endorsement on the ADOS-2 was also examined in AN, REC, and ASD. Across measures, women with ASD showed the highest scores, and TDs the lowest. Generally, individuals with AN and REC showed intermediate levels of ASD symptoms, scoring between the other two groups. However, AN and ASD did not differ on restricted interests and repetitive behaviour subscales. The ADOS-2 item ‘quality of social response’ adequately discriminated between ASD and non-ASD participants. A full diagnostic assessment for ASD was not provided for participants with AN/REC, nor were eating disorders assessed in the ASD group. Therefore, some diagnostic overlap between groups is possible. The cross-sectional design is another limitation. The results suggest similarities in scores on both self-report and clinical interview measures in AN and ASD. However, individual ADOS-2 item analyses also revealed subtle differences, particularly in reciprocal social interaction. ASD symptoms may be a combination of both state and trait features in AN. The online version contains supplementary material available at 10.1186/s13229-021-00455-5.
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