Antibacterial characteristics and activity of water-soluble chitosan derivatives prepared by the Maillard reaction.
Antibacterial characteristics and activity of water-soluble chitosan derivatives prepared by the Maillard reaction.
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DOI:
10.3390/molecules16108504
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发表时间:
2011-10-11
期刊:
影响因子:
--
通讯作者:
Tsai CF
中科院分区:
文献类型:
--
作者:
Chung YC;Yeh JY;Tsai CF
The antibacterial activity of water-soluble chitosan derivatives prepared by Maillard reactions against Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, Escherichia coli, Shigella dysenteriae, and Salmonella typhimurium was examined. Relatively high antibacterial activity against various microorganisms was noted for the chitosan-glucosamine derivative as compared to the acid-soluble chitosan. In addition, it was found that the susceptibility of the test organisms to the water-soluble chitosan derivative was higher in deionized water than in saline solution. Metal ions were also found to reduce the antibacterial activity of the water-soluble chitosan derivative on S. aureus. The marked increase in glucose level, protein content and lactate dehydrogenase (LDH) activity was observed in the cell supernatant of S. aureus exposed to the water-soluble chitosan derivative in deionized water. The results suggest that the water-soluble chitosan produced by Maillard reaction may be a promising commercial substitute for acid-soluble chitosan.
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