Infectious causes of chronic inflammatory diseases and cancer.
Infectious causes of chronic inflammatory diseases and cancer.
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DOI：
10.3201/eid0403.980339
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发表时间：
1998-07
影响因子：
11.8
通讯作者：
Cassell GH
中科院分区：
文献类型：
--
作者：
Cassell GH
强大的诊断技术，再加上认识到，否则不起眼的毒力的生物体可以产生缓慢进行的慢性疾病，具有广泛的临床表现和疾病的结果，导致发现新的传染性病原体和新的概念的传染病。感染的最终结果既取决于患者的遗传背景，也取决于感染因子的遗传组成，这一事实表明，许多病因不明的慢性疾病是由一种或多种感染因子引起的。一个众所周知的例子是发现胃溃疡是由于幽门螺杆菌。支原体可能导致新生儿慢性肺病和成人慢性哮喘，肺炎衣原体是最近发现的急性呼吸道感染的常见原因，与动脉粥样硬化有关。在过去的6年中，已经记录了一些引起或促成人类肿瘤疾病的传染性病原体。慢性炎症性疾病和癌症中感染因子的关联和因果作用对公共卫生、治疗和预防具有重大意义。
Powerful diagnostic technology, plus the realization that organisms of otherwise unimpressive virulence can produce slowly progressive chronic disease with a wide spectrum of clinical manifestations and disease outcomes, has resulted in the discovery of new infectious agents and new concepts of infectious diseases. The demonstration that final outcome of infection is as much determined by the genetic background of the patient as by the genetic makeup of the infecting agent is indicating that a number of chronic diseases of unknown etiology are caused by one or more infectious agents. One well-known example is the discovery that stomach ulcers are due to Helicobacter pylori. Mycoplasmas may cause chronic lung disease in newborns and chronic asthma in adults, and Chlamydia pneumoniae, a recently identified common cause of acute respiratory infection, has been associated with atherosclerosis. A number of infectious agents that cause or contribute to neoplastic diseases in humans have been documented in the past 6 years. The association and causal role of infectious agents in chronic inflammatory diseases and cancer have major implications for public health, treatment, and prevention.
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DOI：
10.1111/j.1749-6632.1973.tb45665.x
发表时间：
1973-01-01
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
CASSELL, GH;LINDSEY, JR;BAKER, HJ
通讯作者：
BAKER, HJ
DOI：
10.1111/j.1440-1754.1993.tb00515.x
发表时间：
1993-08-01
影响因子：
1.7
作者：
DYKE, MP;GRAUAUG, A;ANDREWS, R
通讯作者：
ANDREWS, R
影响因子：
3.6
作者：
BLOCK, S;HEDRICK, J;CRAFT, JC
通讯作者：
CRAFT, JC
影响因子：
9.4
作者：
Blasi, F;Denti, F;Allegra, L
通讯作者：
Allegra, L
影响因子：
3.1
作者：
CROUSE, DT;CASSELL, GH;CASSADY, G
通讯作者：
CASSADY, G