Targeting reduced neural oscillations in patients with schizophrenia by transcranial alternating current stimulation.
Targeting reduced neural oscillations in patients with schizophrenia by transcranial alternating current stimulation.
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DOI：
10.1016/j.neuroimage.2018.10.056
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发表时间：
2019-02-01
期刊：
影响因子：
5.7
通讯作者：
Fröhlich F
中科院分区：
文献类型：
--
作者：
Ahn S;Mellin JM;Alagapan S;Alexander ML;Gilmore JH;Jarskog LF;Fröhlich F
经颅交流电刺激 (tACS) 通过应用具有周期性刺激波形的低幅度电流来调节健康人类参与者的内源性神经振荡。然而，尚不清楚 tACS 是否可以调节和恢复精神分裂症等精神疾病患者减少的神经振荡。在这里，我们询问 tACS 是否可以调节精神分裂症的网络振荡。我们对 22 名患有幻听的精神分裂症患者进行了一项随机、双盲、假对照临床试验，以将 tACS 与经颅直流电刺激 (tDCS) 和假刺激进行对比。我们使用高密度脑电图来研究为期五天、每天两次的 10HztACS 方案是否可以增强 α 振荡并调节精神分裂症中减少的网络动态。我们发现 10Hz-tACS 增强了 α 振荡并调节了 α 频段的功能连接。此外，10Hz-tACS 增强了 40Hz 听觉稳态反应（ASSR），而精神分裂症患者的听觉稳态反应会降低。重要的是，幻听的临床改善与α振荡和40Hz-ASSR的增强相关。总之，我们的研究结果表明，tACS 有潜力作为一种网络级方法来调节与精神分裂症患者临床症状相关的神经振荡的减少。
Transcranial alternating current stimulation (tACS) modulates endogenous neural oscillations in healthy human participants by the application of a low-amplitude electrical current with a periodic stimulation waveform. Yet, it is unclear if tACS can modulate and restore neural oscillations that are reduced in patients with psychiatric illnesses such as schizophrenia. Here, we asked if tACS modulates network oscillations in schizophrenia. We performed a randomized, double-blind, sham-controlled clinical trial to contrast tACS with transcranial direct current stimulation (tDCS) and sham stimulation in 22 schizophrenia patients with auditory hallucinations. We used high-density electroencephalography to investigate if a five-day, twice-daily 10HztACS protocol enhances alpha oscillations and modulates network dynamics that are reduced in schizophrenia. We found that 10Hz-tACS enhanced alpha oscillations and modulated functional connectivity in the alpha frequency band. In addition, 10Hz-tACS enhanced the 40Hz auditory steady-state response (ASSR), which is reduced in patients with schizophrenia. Importantly, clinical improvement of auditory hallucinations correlated with enhancement of alpha oscillations and the 40Hz-ASSR. Together, our findings suggest that tACS has potential as a network-level approach to modulate reduced neural oscillations related to clinical symptoms in patients with schizophrenia.
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影响因子：
2.9
作者：
Ahn S;Nguyen T;Jang H;Kim JG;Jun SC
通讯作者：
Jun SC
影响因子：
6.6
作者：
Ford, Judith M.;Krystal, John H.;Mathalon, Daniel H.
通讯作者：
Mathalon, Daniel H.
DOI：
10.1109/embc.2013.6609968
发表时间：
2013
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
--
作者：
Mullen T;Kothe C;Chi YM;Ojeda A;Kerth T;Makeig S;Cauwenberghs G;Jung TP
通讯作者：
Jung TP
DOI：
10.1177/155005949502600207
发表时间：
1995-04-01
期刊：
CLINICAL ELECTROENCEPHALOGRAPHY
影响因子：
--
作者：
JIN, Y;SANDMAN, CA;POTKIN, SG
通讯作者：
POTKIN, SG
影响因子：
10.6
作者：
MIYAUCHI, T;TANAKA, K;MATSUSHITA, M
通讯作者：
MATSUSHITA, M