Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.
Neuroimaging of Anxiety in Parkinson's Disease: A Systematic Review.
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帕金森氏病焦虑的神经影像学：系统评价。
DOI：
10.1002/mds.28404
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Leentjens AFG
中科院分区：
文献类型：
--
作者：
Carey G;Görmezoğlu M;de Jong JJA;Hofman PAM;Backes WH;Dujardin K;Leentjens AFG
本系统性综述的目的是（1）基于神经影像学研究确定帕金森病（PD）中涉及焦虑的脑区，（2）在恐惧回路和边缘皮质-纹状体-丘脑皮质回路功能障碍的背景下解释研究结果。纳入了评估PD患者焦虑症状的研究以及使用磁共振成像、正电子发射断层扫描或单光子发射计算机断层扫描的研究。焦虑的严重程度与恐惧回路和皮质-纹状体-丘脑皮质边缘回路的变化相关。在恐惧回路中，杏仁核和前扣带回皮质（ACC）的灰质体积减少;杏仁核和眶额皮质（OFC）和海马之间以及纹状体和内侧前额叶皮质（PFC）之间的功能连接性（FC）增加颞叶皮质和岛叶;据报道，外侧前额叶皮质和眶额皮质、海马和杏仁核之间的FC减少。在皮质-纹状体-丘脑皮质边缘回路中，报告了纹状体和ACC之间的FC降低;纹状体、丘脑和蓝斑中多巴胺能和去甲肾上腺素能活性降低;丘脑中多巴胺能活性降低。总之，焦虑与假设的恐惧和边缘皮质-纹状体-丘脑皮质回路的结构和功能变化有关。这些回路相互重叠，很可能构成了一个更广泛的通路的一部分，其中不同的部分在焦虑中扮演着不同的角色。PD的神经病理学可能以不同的方式影响这些回路，解释了PD中焦虑的高患病率以及相关的认知、运动和精神症状。版权所有2020作者。运动障碍由Wiley Periodicals LLC代表国际帕金森和运动障碍协会出版
The aim of this systematic review was (1) to identify the brain regions involved in anxiety in Parkinson's disease (PD) based on neuroimaging studies and (2) to interpret the findings against the background of dysfunction of the fear circuit and limbic cortico‐striato‐thalamocortical circuit. Studies assessing anxiety symptoms in PD patients and studies using magnetic resonance imaging, positron emission tomography, or single‐photon emission computed tomography were included. The severity of anxiety was associated with changes in the fear circuit and the cortico‐striato‐thalamocortical limbic circuit. In the fear circuit, a reduced gray‐matter volume of the amygdala and the anterior cingulate cortex (ACC); an increased functional connectivity (FC) between the amygdala and orbitofrontal cortex (OFC) and hippocampus and between the striatum and the medial prefrontal cortex (PFC), temporal cortex, and insula; and a reduced FC between the lateral PFC and the OFC, hippocampus, and amygdala were reported. In the cortico‐striato‐thalamocortical limbic circuit, a reduced FC between the striatum and ACC; a reduced dopaminergic and noradrenergic activity in striatum, thalamus, and locus coeruleus; and a reduced serotoninergic activity in the thalamus were reported. To conclude, anxiety is associated with structural and functional changes in both the hypothesized fear and the limbic cortico‐striato‐thalamocortical circuits. These circuits overlap and may well constitute parts of a more extensive pathway, of which different parts play different roles in anxiety. The neuropathology of PD may affect these circuits in different ways, explaining the high prevalence of anxiety in PD and also the associated cognitive, motor, and psychiatric symptoms. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
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影响因子：
4.1
作者：
Dissanayaka NNW;Lawson RA;Yarnall AJ;Duncan GW;Breen DP;Khoo TK;Barker RA;Burn DJ;ICICLE-PD study group
通讯作者：
ICICLE-PD study group
影响因子：
2.7
作者：
Hashemiyoon, Rowshanak;Kuhn, Jens;Visser-Vandewalle, Veerle
通讯作者：
Visser-Vandewalle, Veerle
影响因子：
11
作者：
Joling, Merijn;van den Heuvel, Odile A.;Vriend, Chris
通讯作者：
Vriend, Chris
影响因子：
8.6
作者：
Prange, Stephane;Metereau, Elise;Thobois, Stephane
通讯作者：
Thobois, Stephane
影响因子：
7.8
作者：
Osorio, F. L.;Crippa, J. A. S.;Loureiro, S. R.
通讯作者：
Loureiro, S. R.