Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines.
Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines.
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化学酶动态动力学拆分：制备对映体纯醇和胺的强大工具。
DOI：
10.1021/jacs.5b01031
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发表时间：
2015-04-01
影响因子：
15
通讯作者：
Bäckvall JE
中科院分区：
文献类型：
--
作者：
Verho O;Bäckvall JE
化学酶动态动力学拆分(DKR)是一种方便、高效地获得对映体纯醇和胺类化合物的方法。这一视角突出了过去二十年来在这一领域内开展的工作，并指出了今后研究的重要途径。首先，透视将概述酒精DKR更发达的领域，勾勒出从最早的概念验证协议到当前最先进的系统，这些系统允许高效和选择性地制备各种对映体纯醇衍生物。此后，透视将通过介绍目前可用的均相和非均相方法及其各自的局限性，集中于更具挑战性的胺的DKR。在这两个部分中，将致力于设计高效的外消旋方法，作为开发更温和的DKR协议的重要手段。在透视的最后部分，简要概述了致力于提高酶作为生物催化剂的研究。
Chemoenzymatic dynamic kinetic resolution (DKR) constitutes a convenient and efficient method to access enantiomerically pure alcohol and amine derivatives. This Perspective highlights the work carried out within this field during the past two decades and pinpoints important avenues for future research. First, the Perspective will summarize the more developed area of alcohol DKR, by delineating the way from the earliest proof-of-concept protocols to the current state-of-the-art systems that allows for the highly efficient and selective preparation of a wide range of enantiomerically pure alcohol derivatives. Thereafter, the Perspective will focus on the more challenging DKR of amines, by presenting the currently available homogeneous and heterogeneous methods and their respective limitations. In these two parts, significant attention will be dedicated to the design of efficient racemization methods as an important means of developing milder DKR protocols. In the final part of the Perspective, a brief overview of the research that has been devoted toward improving enzymes as biocatalysts is presented.
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影响因子：
3.6
作者：
Choi, JH;Choi, YK;Park, JW
通讯作者：
Park, JW
影响因子：
15
作者：
Aberg, Jenny B.;Warner, Madeleine C.;Backvall, Jan-E.
通讯作者：
Backvall, Jan-E.
影响因子：
1.8
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通讯作者：
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5.2
作者：
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通讯作者：
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影响因子：
16.6
作者：
Berkessel, Albrecht;Sebastian-Ibarz, M. Luisa;Mueller, Thomas N.
通讯作者：
Mueller, Thomas N.