Acute infections and venous thromboembolism.
Acute infections and venous thromboembolism.
复制标题
DOI：
10.1111/j.1365-2796.2011.02473.x
复制
发表时间：
2012-06
影响因子：
11.1
通讯作者：
Sørensen HT
中科院分区：
文献类型：
--
作者：
Schmidt M;Horvath-Puho E;Thomsen RW;Smeeth L;Sørensen HT
施密特·M、霍瓦特·普霍·E、汤姆森·R·W、斯梅特·L、S·伦森·HT(丹麦奥胡斯大学医院临床医学研究所临床流行病学系；英国伦敦伦敦卫生和热带医学院非传染性流行病学系)。急性感染和静脉血栓形成。J实习生医学杂志2012；271：608-618。关于急性感染和静脉血栓栓塞症(VTE)之间的联系的数据很少。我们检查了各种医院诊断的感染或社区治疗的感染是否会增加VTE的风险。我们使用医学数据库在丹麦北部(人口180万)进行了这项基于人群的病例对照研究。我们确定了1999-2009年间所有首次被医院诊断为静脉血栓栓塞症的患者(n=15 009)。对于每个病例，我们从年龄、性别和居住地匹配的普通人群中选择了10名对照(n=150 074)。我们在VTE前一年确定了所有医院诊断的感染和社区抗生素处方。我们使用条件Logistic回归模型中的优势比估计感染后第一年不同时间间隔内静脉血栓栓塞症的发生率比(IRR)，控制混杂因素。在医院诊断或在社区治疗的呼吸道、尿路、皮肤、腹内和菌血症感染与静脉血栓栓塞症风险增加两倍以上相关。这种关联在感染发生后的头两周内最强，此后逐渐下降。与VTE前一年未感染的患者相比，医院诊断感染的患者在感染后前3个月内的IRR为12.5(95%可信区间：11.3~13.9)，社区使用抗生素患者的IRR为4.0(95%CI：3.8~4.1)。调整VTE危险因素后，这些IRR分别降至3.3(95%CI：2.9-3.8)和2.6(95%CI：2.5-2.8)。无缘无故的静脉血栓形成、深静脉血栓形成和肺栓塞也有类似的相关性。感染是静脉血栓栓塞症的风险因素。
Schmidt M, Horvath-Puho E, Thomsen RW, Smeeth L, Sørensen HT (Department of Clinical Epidemiology, Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark; and Department of Non-Communicable Epidemiology, London School of Hygiene and Tropical Medicine, London, UK). Acute infections and venous thromboembolism. J Intern Med 2012; 271: 608–618. Data on the association between acute infections and venous thromboembolism (VTE) are sparse. We examined whether various hospital-diagnosed infections or infections treated in the community increase the risk of VTE. We conducted this population-based case–control study in Northern Denmark (population 1.8 million) using medical databases. We identified all patients with a first hospital-diagnosed VTE during the period 1999–2009 (n = 15 009). For each case, we selected 10 controls from the general population matched for age, gender and county of residence (n = 150 074). We identified all hospital-diagnosed infections and community prescriptions for antibiotics 1 year predating VTE. We used odds ratios from a conditional logistic regression model to estimate incidence rate ratios (IRRs) of VTE within different time intervals of the first year after infection, controlling for confounding. Respiratory tract, urinary tract, skin, intra-abdominal and bacteraemic infections diagnosed in hospital or treated in the community were associated with a greater than equal to twofold increased VTE risk. The association was strongest within the first 2 weeks after infection onset, gradually declining thereafter. Compared with individuals without infection during the year before VTE, the IRR for VTE within the first 3 months after infection was 12.5 (95% confidence interval (CI): 11.3–13.9) for patients with hospital-diagnosed infection and 4.0 (95% CI: 3.8–4.1) for patients treated with antibiotics in the community. Adjustment for VTE risk factors reduced these IRRs to 3.3 (95% CI: 2.9–3.8) and 2.6 (95% CI: 2.5–2.8), respectively. Similar associations were found for unprovoked VTE and for deep venous thrombosis and pulmonary embolism individually. Infections are a risk factor for VTE.
登录
查看更多内容
影响因子：
7.2
作者：
Severinsen, Marianne Tang;Kristensen, Soren Risom;Johnsen, Soren Paaske
通讯作者：
Johnsen, Soren Paaske
影响因子：
2.7
作者：
BELCH, JJ;LOWE, GDO;PRENTICE, CRM
通讯作者：
PRENTICE, CRM
影响因子：
3.9
作者：
Ehrenstein, Vera;Antonsen, Sussie;Pedersen, Lars
通讯作者：
Pedersen, Lars
影响因子：
7.7
作者：
Clayton, Tim C.;Gaskin, Marion;Meade, Tom W.
通讯作者：
Meade, Tom W.
影响因子：
1.1
作者：
Alikhan, R;Cohen, AT;Turpie, AGG
通讯作者：
Turpie, AGG