Coherent oscillatory networks supporting short-term memory retention.

Coherent oscillatory networks supporting short-term memory retention.
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DOI:
10.1016/j.brainres.2008.09.095
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发表时间:
2009-01-09
期刊:
影响因子:
2.9
通讯作者:
Kounios J
Kounios J
中科院分区:
医学3区
文献类型:
--
作者:
Payne L;Kounios J

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越来越多的证据表明,自上而下的过程,反映了额叶中线θ带(4-8 Hz)的脑电图(EEG)振荡,加强激活的记忆集在短期记忆(STM)的保留。此外,STM保持期间后部α波段(8-13 Hz)振荡的幅度被认为反映了一种机制,该机制通过门控自下而上的感觉输入来保护脆弱的STM激活免受干扰。本研究解决了两个重要的问题,这些现象。首先,为什么以前的研究没有一致地发现记忆集大小对额中线θ的影响?第二,后α如何参与STM保持?为了回答这些问题,本研究探讨了大规模的网络连接STM保留期间计算EEG小波相干保留期间的一个修改后的斯滕贝格任务,使用视觉呈现的字母作为刺激。结果显示:(a)随着记忆负荷的增加,额中线和左颞顶叶部位之间的θ波相干性增加,(b)随着记忆负荷的增加,中线顶叶和左颞/顶叶部位之间的α波相干性增加。(B)随着记忆负荷的增加,中线顶叶和左颞/顶叶部位之间的α波相干性增加。这些研究结果支持了这样的观点,即θ-波段的相干性,而不是振幅,是选择性自上而下加强记忆集的关键因素,并表明,与感觉门控相关的后α-波段振荡参与STM保持通过参与STM网络。
Accumulating evidence suggests that top-down processes, reflected by frontal-midline theta-band (4-8 Hz) electroencephalogram (EEG) oscillations, strengthen the activation of a memory set during short-term memory (STM) retention. In addition, the amplitude of posterior alpha-band (8-13 Hz) oscillations during STM retention is thought to reflect a mechanism that protects fragile STM activations from interference by gating bottom-up sensory inputs. The present study addressed two important questions about these phenomena. First, why have previous studies not consistently found memory set-size effects on frontal-midline theta? Second, how does posterior alpha participate in STM retention? To answer these questions, the present study examined large-scale network connectivity during STM retention by computing EEG wavelet coherence during the retention period of a modified Sternberg task using visually-presented letters as stimuli. The results showed (a) increasing theta-band coherence between frontal-midline and left temporal-parietal sites with increasing memory load, and (b) increasing alpha-band coherence between midline parietal and left temporal/parietal sites with increasing memory load. These findings support the view that theta-band coherence, rather than amplitude, is the key factor in selective top-down strengthening of the memory set and demonstrate that posterior alpha-band oscillations associated with sensory gating are involved in STM retention by participating in the STM network.
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