Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial.
Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial.
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DOI：
10.1016/j.schres.2018.09.013
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发表时间：
2019-03
影响因子：
4.5
通讯作者：
Penn D
中科院分区：
文献类型：
--
作者：
Halverson T;Jarskog LF;Pedersen C;Penn D
鼻内催产素是一种参与亲社会行为和调节社会认知和情绪调节神经网络的神经肽，其作用已在精神分裂症中进行了研究。我们测试了一个假设，即每天两次鼻内催产素给药12周，将改善三级和探索性的结果自我报告的社会症状，同情和内省的准确性，从随机对照试验。68名稳定的精神分裂症或情感障碍门诊患者随机接受催产素（24 IU，每日两次）或安慰剂。用特定功能水平量表和人际知觉任务评估内省的准确性。使用人际反应指数（IRI）评估同理心，使用利博维茨社交焦虑量表和绿色等人的偏执思想量表评估社交症状。在基线、6周和12周时评估结局。结果表明，催产素的影响有限，IRI观点采择分量表有一定的改善。在自我报告的症状、同理心或内省的准确性方面，没有出现额外的组间差异。
The effects of intranasal oxytocin, a neuropeptide involved in prosocial behavior and modulation of neural networks underlying social cognition and emotion regulation, have been studied in schizophrenia. We tested the hypothesis that twice-daily intranasal oxytocin administered for 12-weeks would improve tertiary and exploratory outcomes of self-reported social symptoms, empathy and introspective accuracy from the randomized controlled trial. Sixty-eight stable outpatients with schizophrenia or schizoaffective disorder were randomized to receive oxytocin (24 IU twice daily) or placebo. Introspective accuracy was assessed with the Specific Level of Functioning Scale and the Interpersonal Perception Task. Empathy was assessed with the Interpersonal Reactivity Index (IRI), and social symptoms were assessed with the Liebowitz Social Anxiety Scale and the Green et al. Paranoid Thoughts Scales. Outcomes were assessed at baseline, six, and twelve weeks. Results demonstrated limited effect of oxytocin with some improvement on the IRI Perspective-Taking Subscale. No additional between-group differences emerged on self-reported symptoms, empathy, or introspective accuracy.
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