Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward.
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward.
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DOI：
10.1016/j.neubiorev.2017.05.007
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发表时间：
2017-09
影响因子：
8.2
通讯作者：
Woolley JD
中科院分区：
文献类型：
--
作者：
Bradley ER;Woolley JD
精神分裂症是一种严重的精神疾病，会导致严重的功能障碍。目前的药物治疗是不够的，特别是解决负面和认知症状的障碍。催产素是一种调节社会行为的神经肽，近年来被研究为精神分裂症的潜在治疗药物。结果显然是喜忧参半的，导致了关于催产素效用的争议。在这篇综述中，我们概述了几个考虑因素，解释现存的文献，并提出了一个重点议程，为今后的工作，建立在最引人注目的发现催产素对精神分裂症的影响。具体来说，我们研究异质性的根本原因在随机临床试验（RCT）进行至今，并强调人类催产素系统的复杂性。然后，我们审查证据催产素的具体缺陷精神分裂症的影响，主张进一步研究，使用客观，精确的结果的措施，以确定催产素是否有潜力改善精神分裂症的功能障碍。
Schizophrenia is a severe mental illness that causes major functional impairment. Current pharmacologic treatments are inadequate, particularly for addressing negative and cognitive symptoms of the disorder. Oxytocin, a neuropeptide known to moderate social behaviors, has been investigated as a potential therapeutic for schizophrenia in recent years. Results have been decidedly mixed, leading to controversy regarding oxytocin's utility. In this review, we outline several considerations for interpreting the extant literature and propose a focused agenda for future work that builds on the most compelling findings regarding oxytocin effects in schizophrenia to date. Specifically, we examine underlying causes of heterogeneity in randomized clinical trials (RCTs) conducted thus far and highlight the complexity of the human oxytocin system. We then review evidence of oxytocin's effects on specific deficits in schizophrenia, arguing for further study using objective, precise outcome measures in order to determine whether oxytocin has the potential to improve functional impairment in schizophrenia.
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