Self-assembly of phospholipid-PEG coating on nanoparticles through dual solvent exchange.

Self-assembly of phospholipid-PEG coating on nanoparticles through dual solvent exchange.
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通过双溶剂交换在纳米颗粒上磷脂涂层的自组装。

DOI:
10.1021/nl201978c
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发表时间:
2011-09-14
期刊:
影响因子:
10.8
通讯作者:
Bao G
Bao G
中科院分区:
材料科学1区
文献类型:
--
作者:
Tong S;Hou S;Ren B;Zheng Z;Bao G

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我们使用新开发的双溶剂交换法用磷脂-PEG包覆纳米粒子,包括氧化铁纳米粒子和量子点,并证明,与传统的膜水合法相比,包覆纳米粒子的包覆效率和质量可以显着提高。实现了对表面涂层密度和纳米颗粒表面反应基团数量的更好控制,允许不同部分以所需的表面浓度缀合,从而促进纳米颗粒的生物医学应用。
We coated nanoparticles including iron oxide nanoparticles and quantum dots with phospholipid-PEG using the newly developed dual solvent exchange method and demonstrated that, compared with the conventional film hydration method, the coating efficiency and quality of coated nanoparticles can be significantly improved. A better control of surface coating density and the amount of reactive groups on nanoparticle surface is achieved, allowing conjugation of different moieties with desirable surface concentrations, thus facilitating biomedical applications of nanoparticles.
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