Tuning the interactions between chiral plasmonic films and living cells.

Tuning the interactions between chiral plasmonic films and living cells.
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调节手性等离子体薄膜和活细胞之间的相互作用

DOI:
10.1038/s41467-017-02268-8
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发表时间:
2017-12-08
影响因子:
16.6
通讯作者:
Kuang H
Kuang H
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Zhao X;Xu L;Sun M;Ma W;Wu X;Xu C;Kuang H

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设计手性材料来调控细胞的生物活性,不仅是化学和材料科学的一个重要领域,而且也是细胞生物学和生物医学的一个重要领域。在这里,我们介绍了单层等离子体手性Au纳米粒子(NP)膜修饰的l- ord-penicillamine(Pen)开发的细胞生长,分化和检索。单层膜显示出高的手性活性,圆二色性值为3.5 mdeg在550 nm和26.8 mdeg在775 nm。Thel-Pen-NP膜促进细胞增殖,而d-Pen-NP膜具有相反的效果。选择用光的远程照射来非侵入性地收集细胞。结果表明,左旋圆偏振光使l-Pen-NP膜的细胞脱离效率提高至91.2%。这些发现将促进细胞培养在生物医学应用中的发展,并有助于理解天然同手性。
Designing chiral materials to manipulate the biological activities of cells has been an important area not only in chemistry and material science, but also in cell biology and biomedicine. Here, we introduce monolayer plasmonic chiral Au nanoparticle (NP) films modified withl- ord-penicillamine (Pen) to be developed for cell growth, differentiation, and retrieval. The monolayer films display high chiroptical activity, with circular dichroism values of 3.5 mdeg at 550 nm and 26.8 mdeg at 775 nm. Thel-Pen-NP films accelerate cell proliferation, whereas thed-Pen-NP films have the opposite effect. Remote irradiation with light is chosen to noninvasively collect the cells. The results demonstrate that left circularly polarized light improves the efficiency of cell detachment up to 91.2% forl-Pen-NP films. These findings will facilitate the development of cell culture in biomedical application and help to understand natural homochirality.
DOI: 10.1002/adma.201501351
发表时间: 2015-07-15
期刊: Advanced materials (Deerfield Beach, Fla.)
影响因子: --
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Celiz AD;Smith JG;Patel AK;Hook AL;Rajamohan D;George VT;Flatt L;Patel MJ;Epa VC;Singh T;Langer R;Anderson DG;Allen ND;Hay DC;Winkler DA;Barrett DA;Davies MC;Young LE;Denning C;Alexander MR
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DOI: 10.1038/ncomms13500
发表时间: 2016-12-01
影响因子: 16.6
作者:
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通讯作者: Verfaillie, Catherine M.