Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair.
Mesenchymal stem cells: paracrine signaling and differentiation during cutaneous wound repair.
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DOI：
10.1016/j.yexcr.2010.05.009
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发表时间：
2010-08-15
影响因子：
3.7
通讯作者：
Gibran NS
中科院分区：
文献类型：
--
作者：
Hocking AM;Gibran NS
尽管人们对损伤的细胞和分子反应的了解有所增加，但皮肤伤口仍然是一个医疗危机。造成这场危机的主要原因是缺乏可靠的疗法来治疗愈合缓慢的伤口，包括慢性伤口和会形成肥厚性疤痕的深层真皮伤口。本文将回顾越来越多的证据，证明多能间充质干/基质 (MSC) 在治疗伤口愈合受损方面的前景。间充质干细胞通常被称为间充质干细胞，尽管由于缺乏证据证明体内自我更新，人们担心这些细胞不是真正的干细胞。无论如何，大量证据表明间充质干细胞对于修复和再生因损伤或疾病而受损的组织具有治疗潜力。迄今为止，间充质干细胞治疗急性和慢性伤口可加速伤口闭合，增加上皮化、肉芽组织形成和血管生成。尽管有证据表明间充质干细胞在伤口中分化，但大多数治疗效果可能是由于间充质干细胞释放可溶性因子来调节局部细胞对皮肤损伤的反应。在 MSC 能够有效地用于治疗愈合缓慢的伤口之前，需要克服重要的挑战。
Cutaneous wounds persist as a health care crisis in spite of increased understanding of the cellular and molecular responses to injury. Contributing significantly to this crisis is the lack of reliable therapies for treatment of wounds that are slow to heal including chronic wounds and deep dermal wounds that develop hypertrophic scars. This article will review the growing evidence demonstrating the promise of multipotent mesenchymal stem/stromal (MSCs) for the treatment of impaired wound healing. MSCs are often referred to as mesenchymal stem cells despite concerns that these cells are not truly stem cells given the lack of evidence demonstrating self-renewal in vivo. Regardless, abundant evidence demonstrates the therapeutic potential of MSCs for repair and regeneration of damaged tissue due to injury or disease. To date, MSC treatment of acute and chronic wounds results in accelerated wound closure with increased epithelialization, granulation tissue formation and angiogenesis. Although there is evidence for MSC differentiation in the wound, most of the therapeutic effects are likely due to MSCs releasing soluble factors that regulate local cellular responses to cutaneous injury. Important challenges need to be overcome before MSCs can be used effectively to treat wounds that are slow to heal.
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影响因子：
6.2
作者：
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通讯作者：
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影响因子：
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DOI：
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影响因子：
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