SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?
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DOI:
10.1039/c7bm00515f
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发表时间:
2017-12-19
影响因子:
6.6
通讯作者:
Adams DJ
Adams DJ
中科院分区:
工程技术2区
文献类型:
--
作者:
Barrow M;Taylor A;Fuentes-Caparrós AM;Sharkey J;Daniels LM;Mandal P;Park BK;Murray P;Rosseinsky MJ;Adams DJ

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主要由磁铁矿或磁赤铁矿组成的SPION在溶液中显示出不同的化学稳定性,但在细胞中具有相同的成像特性。虽然有大量的文献涵盖了超顺磁性氧化铁纳米颗粒(SPION)的生物医学应用,但在考虑再生医学的细胞标记和跟踪研究时,通常不考虑所使用的氧化铁核心的相。在这里,我们使用共沉淀反应来合成磁铁矿-(Fe 3 O 4)和磁赤铁矿-(γ-Fe 2 O3)基核的颗粒,并考虑制造磁赤铁矿基颗粒的额外合成步骤是否有利于细胞追踪。
SPIONs consisting predominantly of magnetite or maghemite display distinct chemical stability in solution but equivalent imaging properties when in cells. Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. Here, we use a co-precipitation reaction to synthesise particles of both magnetite- (Fe3O4) and maghemite- (γ-Fe2O3) based cores and consider whether the extra synthesis step to make maghemite based particles is advantageous for cell tracking.
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