An Open Resource for Non-human Primate Optogenetics.
An Open Resource for Non-human Primate Optogenetics.
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DOI：
10.1016/j.neuron.2020.09.027
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发表时间：
2020-12-23
期刊：
影响因子：
16.2
通讯作者：
Platt ML
中科院分区：
文献类型：
--
作者：
Tremblay S;Acker L;Afraz A;Albaugh DL;Amita H;Andrei AR;Angelucci A;Aschner A;Balan PF;Basso MA;Benvenuti G;Bohlen MO;Caiola MJ;Calcedo R;Cavanaugh J;Chen Y;Chen S;Chernov MM;Clark AM;Dai J;Debes SR;Deisseroth K;Desimone R;Dragoi V;Egger SW;Eldridge MAG;El-Nahal HG;Fabbrini F;Federer F;Fetsch CR;Fortuna MG;Friedman RM;Fujii N;Gail A;Galvan A;Ghosh S;Gieselmann MA;Gulli RA;Hikosaka O;Hosseini EA;Hu X;Hüer J;Inoue KI;Janz R;Jazayeri M;Jiang R;Ju N;Kar K;Klein C;Kohn A;Komatsu M;Maeda K;Martinez-Trujillo JC;Matsumoto M;Maunsell JHR;Mendoza-Halliday D;Monosov IE;Muers RS;Nurminen L;Ortiz-Rios M;O'Shea DJ;Palfi S;Petkov CI;Pojoga S;Rajalingham R;Ramakrishnan C;Remington ED;Revsine C;Roe AW;Sabes PN;Saunders RC;Scherberger H;Schmid MC;Schultz W;Seidemann E;Senova YS;Shadlen MN;Sheinberg DL;Siu C;Smith Y;Solomon SS;Sommer MA;Spudich JL;Stauffer WR;Takada M;Tang S;Thiele A;Treue S;Vanduffel W;Vogels R;Whitmire MP;Wichmann T;Wurtz RH;Xu H;Yazdan-Shahmorad A;Shenoy KV;DiCarlo JJ;Platt ML
光遗传学已经彻底改变了小型实验室动物的神经科学，但它对与人类关系更密切的动物模型（如非人类灵长类动物（NHP））的影响却喜忧参半。为了在灵长类动物光遗传学中做出基于证据的决策，科学界将受益于一个集中的数据库，该数据库列出了在灵长类动物大脑中使用光遗传学的所有成功和不成功的尝试。我们联系了社区成员，要求他们为开放科学计划做出贡献。截至撰写本文时，全球45个实验室贡献了1000多个注射实验，包括有关其方法和结果的精确细节。在这些条目中，一半以上尚未发表。该资源是免费的，每个人都可以在开放科学框架网站上查阅和贡献。在这里，我们回顾了数据库首次发布的一些见解，并讨论了提高NHP中光遗传学实验成功率的方法学考虑因素。
Optogenetics has revolutionized neuroscience in small laboratory animals, but its impact on animal models more closely related to humans, such as non-human primates (NHP), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, at using optogenetics in the primate brain. We contacted members of the community to ask for their contribution to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1000 injection experiments, including precise details about their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult, and to contribute to, on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHP.
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影响因子：
2.9
作者：
Bohlen, Martin O.;El-Nahal, Hala G.;Sommer, Marc A.
通讯作者：
Sommer, Marc A.
影响因子：
9.2
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Dai, Ji;Brooks, Daniel I.;Sheinberg, David L.
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影响因子：
25
作者：
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Deisseroth, K
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17.1
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通讯作者：
Boyden, Edward S.
影响因子：
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作者：
Deisseroth, Karl
通讯作者：
Deisseroth, Karl