Dyslipidemia in obesity: mechanisms and potential targets.
Dyslipidemia in obesity: mechanisms and potential targets.
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DOI：
10.3390/nu5041218
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发表时间：
2013-04-12
期刊：
影响因子：
5.9
通讯作者：
Cabezas MC
中科院分区：
文献类型：
--
作者：
Klop B;Elte JW;Cabezas MC
肥胖已成为一个主要的世界性健康问题。在世界上每一个国家，肥胖症的发病率都在不断上升，因此，相关的发病率、死亡率以及医疗和经济成本预计也会增加。这些并发症中的大多数与合并症有关，包括冠状动脉疾病、高血压、2型糖尿病、呼吸系统疾病和血脂异常。肥胖通过风险因素增加心血管风险，如空腹血浆甘油三酯增加，高LDL胆固醇，低HDL胆固醇，血糖和胰岛素水平升高以及高血压。与肥胖相关的新的脂质依赖性代谢风险因素是存在小密度LDL表型、餐后高脂血症伴致动脉粥样硬化残余物积聚和含apoB脂蛋白的肝脏过度产生。所有这些脂质异常都是代谢综合征的典型特征，并且可能与促炎梯度相关，促炎梯度部分可能起源于脂肪组织本身并直接影响内皮。肥胖、代谢综合征和血脂异常之间的一个重要联系似乎是外周组织中胰岛素抵抗的发展，导致来自饮食来源、血管内脂解和来自对胰岛素的抗脂解作用有抗性的脂肪组织的脂肪酸的肝通量增强。现就肥胖与脂代谢的关系及可能的干预措施作一综述。
Obesity has become a major worldwide health problem. In every single country in the world, the incidence of obesity is rising continuously and therefore, the associated morbidity, mortality and both medical and economical costs are expected to increase as well. The majority of these complications are related to co-morbid conditions that include coronary artery disease, hypertension, type 2 diabetes mellitus, respiratory disorders and dyslipidemia. Obesity increases cardiovascular risk through risk factors such as increased fasting plasma triglycerides, high LDL cholesterol, low HDL cholesterol, elevated blood glucose and insulin levels and high blood pressure. Novel lipid dependent, metabolic risk factors associated to obesity are the presence of the small dense LDL phenotype, postprandial hyperlipidemia with accumulation of atherogenic remnants and hepatic overproduction of apoB containing lipoproteins. All these lipid abnormalities are typical features of the metabolic syndrome and may be associated to a pro-inflammatory gradient which in part may originate in the adipose tissue itself and directly affect the endothelium. An important link between obesity, the metabolic syndrome and dyslipidemia, seems to be the development of insulin resistance in peripheral tissues leading to an enhanced hepatic flux of fatty acids from dietary sources, intravascular lipolysis and from adipose tissue resistant to the antilipolytic effects of insulin. The current review will focus on these aspects of lipid metabolism in obesity and potential interventions to treat the obesity related dyslipidemia.
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影响因子：
8.7
作者：
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通讯作者：
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影响因子：
56.9
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影响因子：
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影响因子：
5.3
作者：
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通讯作者：
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