Uniformity of cardiac (123)I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia.
Uniformity of cardiac (123)I-MIBG uptake on SPECT images in older adults with normal cognition and patients with dementia.
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DOI：
10.1007/s12350-019-01977-5
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Thomas AJ
中科院分区：
文献类型：
--
作者：
Roberts G;Lloyd JJ;Jefferson E;Kane JPM;Durcan R;Lawley S;Petrides GS;Howe K;Haq I;O'Brien JT;Thomas AJ
一些研究报告称，评估区域 123I 心脏 MIBG 摄取有助于诊断路易体病，但其他研究报告称健康对照中存在异质性。我们的目的是评估健康老年人和痴呆症患者的区域心脏 MIBG 摄取模式。招募了 31 名认知正常的老年人、15 名阿尔茨海默病 (AD) 和 17 名路易体痴呆 (DLB) 患者。 5 人既往患有心肌梗塞。具有足够心脏摄取进行区域 SPECT 分析的参与者（29/31 对照、15/15 AD、5/17 DLB）记录了相对摄取模式。使用 QRISK2（一种经过验证的在线工具）评估对照者未来心血管事件的风险。在对照中，下壁（85%）、心尖（23%）、隔膜（15%）和侧壁（8%）的摄取减少。 AD 和 DLB 显示与对照组相似的模式。 61% 的病例存在肺部或肝脏干扰。心肌梗塞病例显示区域摄取减少，但平面摄取正常/临界。在对照组中，心血管风险评分和摄取模式之间没有关系。在平面心脏摄取正常的病例中，区域心脏 123I-MIBG 摄取的显着变异很常见。区域摄取的异质性似乎是非特异性的，不太可能有助于路易体病的诊断。本文的在线版本 (10.1007/s12350-019-01977-5) 包含补充材料，可供授权用户使用。
Some studies report that assessing regional 123I-cardiac MIBG uptake can aid in the diagnosis of Lewy body disease, but others report heterogeneity in healthy controls. We aimed to evaluate regional cardiac MIBG uptake patterns in healthy older adults and patients with dementia. 31 older adults with normal cognition, 15 Alzheimer’s disease (AD), and 17 Dementia with Lewy bodies (DLB) patients were recruited. 5 individuals had previous myocardial infarction. Participants with sufficient cardiac uptake for regional SPECT analysis (29/31 controls, 15/15 AD, 5/17 DLB) had relative uptake pattern recorded. Controls were assessed for risk of future cardiovascular events using QRISK2, a validated online tool. In controls uptake was reduced in the inferior wall (85%), apex (23%), septum (15%), and lateral wall (8%). AD and DLB showed similar patterns to controls. Lung or liver interference was present in 61% of cases. Myocardial infarction cases showed regional reductions in uptake, but normal/borderline planar uptake. In controls, there was no relationship between cardiovascular risk score and uptake pattern. Significant variability of regional cardiac 123I-MIBG uptake is common in cases with normal planar cardiac uptake. Heterogeneity of regional uptake appears non-specific and unlikely to aid in the diagnosis of Lewy body disease. The online version of this article (10.1007/s12350-019-01977-5) contains supplementary material, which is available to authorized users.
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DOI：
10.1186/alzrt274
发表时间：
2014
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Donaghy PC;McKeith IG
通讯作者：
McKeith IG
影响因子：
1.5
作者：
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通讯作者：
Yano, K
DOI：
10.1007/s00259-015-2989-6
发表时间：
2015-06-01
影响因子：
9.1
作者：
Lebasnier, Adrien;Lamotte, Guillaume;Agostini, Denis
通讯作者：
Agostini, Denis
影响因子：
5.1
作者：
Hanyu, H.;Sato, T.;Iwamoto, T.
通讯作者：
Iwamoto, T.
DOI：
10.1186/s13195-018-0350-6
发表时间：
2018-02-15
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Kane JPM;Surendranathan A;Bentley A;Barker SAH;Taylor JP;Thomas AJ;Allan LM;McNally RJ;James PW;McKeith IG;Burn DJ;O'Brien JT
通讯作者：
O'Brien JT