Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus.
Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus.
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DOI：
10.3390/biom11070928
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发表时间：
2021-06-22
期刊：
影响因子：
5.5
通讯作者：
Fujio K
中科院分区：
文献类型：
--
作者：
Yu H;Nagafuchi Y;Fujio K
系统性红斑狼疮 (SLE) 的特点是免疫系统功能障碍，临床表现多样，表现出肾脏、皮肤病、神经精神和心血管症状。临床和生理评估通常不足以诊断和评估 SLE 的病理生理过程。临床和免疫生物标志物可以在改善 SLE 的诊断、评估和最终控制方面发挥关键作用。本文综述了可诊断和监测 SLE 疾病活动的临床和免疫生物标志物，无论是否存在器官特异性损伤。此外，还回顾了通过“组学”研究发现的新型 SLE 生物标志物。
Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and cardiovascular symptoms. Clinical and physiological assessment is usually inadequate for diagnosing and assessing pathophysiological processes in SLE. Clinical and immunological biomarkers could play a critical role in improving diagnosis, assessment, and ultimately, control of SLE. This article reviews clinical and immunological biomarkers that could diagnose and monitor disease activity in SLE, with and without organ-specific injury. In addition, novel SLE biomarkers that have been discovered through “omics” research are also reviewed.
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