Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology.
Insights Into the Molecular Mechanisms of T Follicular Helper-Mediated Immunity and Pathology.
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DOI：
10.3389/fimmu.2018.01884
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发表时间：
2018
影响因子：
7.3
通讯作者：
Nurieva R
中科院分区：
文献类型：
--
作者：
Qin L;Waseem TC;Sahoo A;Bieerkehazhi S;Zhou H;Galkina EV;Nurieva R
滤泡辅助性T细胞（Tfh）在生殖中心（GC）反应中为B细胞提供帮助方面起关键作用。针对各种感染的保护性抗体的产生是Tfh介导的免疫应答的重要方面，并且Tfh细胞应答的失调已经涉及各种自身免疫性病症、炎症和恶性肿瘤。因此，它们的分化和维持必须被密切调节以确保对B细胞的适当帮助。Tfh细胞的产生和功能受多个检查点调节，包括其在T区的早期引发阶段和GC中分化的整个效应阶段。细胞因子和共刺激受体下游激活的信号通路以及随后亚群特异性转录因子的激活是Tfh细胞生成的重要步骤。因此，了解Tfh细胞介导的免疫和病理学的机制将使人们关注新疗法的潜在靶点。在这篇综述中，我们讨论了与Tfh细胞分化的分子机制及其在正常免疫反应和抗体介导的疾病中的作用相关的最新发现。
T follicular helper (Tfh) cells play key role in providing help to B cells during germinal center (GC) reactions. Generation of protective antibodies against various infections is an important aspect of Tfh-mediated immune responses and the dysregulation of Tfh cell responses has been implicated in various autoimmune disorders, inflammation, and malignancy. Thus, their differentiation and maintenance must be closely regulated to ensure appropriate help to B cells. The generation and function of Tfh cells is regulated by multiple checkpoints including their early priming stage in T zones and throughout the effector stage of differentiation in GCs. Signaling pathways activated downstream of cytokine and costimulatory receptors as well as consequent activation of subset-specific transcriptional factors are essential steps for Tfh cell generation. Thus, understanding the mechanisms underlying Tfh cell-mediated immunity and pathology will bring into spotlight potential targets for novel therapies. In this review, we discuss the recent findings related to the molecular mechanisms of Tfh cell differentiation and their role in normal immune responses and antibody-mediated diseases.
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影响因子：
30.5
作者：
Butler, Noah S.;Moebius, Jacqueline;Pewe, Lecia L.;Traore, Boubacar;Doumbo, Ogobara K.;Tygrett, Lorraine T.;Waldschmidt, Thomas J.;Crompton, Peter D.;Harty, John T.
通讯作者：
Harty, John T.
DOI：
10.1073/pnas.1205834109
发表时间：
2012-05-29
影响因子：
11.1
作者：
Bollig, Nadine;Bruestle, Anne;Lohoff, Michael
通讯作者：
Lohoff, Michael
DOI：
10.1111/ajt.14400
发表时间：
2018-01
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
--
作者：
Badell IR;La Muraglia GM 2nd;Liu D;Wagener ME;Ding G;Ford ML
通讯作者：
Ford ML
影响因子：
7.3
作者：
Andris F;Denanglaire S;Anciaux M;Hercor M;Hussein H;Leo O
通讯作者：
Leo O
影响因子：
7.7
作者：
Arif S;Leete P;Nguyen V;Marks K;Nor NM;Estorninho M;Kronenberg-Versteeg D;Bingley PJ;Todd JA;Guy C;Dunger DB;Powrie J;Willcox A;Foulis AK;Richardson SJ;de Rinaldis E;Morgan NG;Lorenc A;Peakman M
通讯作者：
Peakman M