Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis
Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis
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2 型糖尿病与抑郁症存在因果关系：孟德尔随机分析
DOI：
10.1007/s11684-018-0671-7
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发表时间：
2018-11
影响因子：
8.1
通讯作者：
Xu Min
中科院分区：
文献类型：
--
作者：
Xuan Liping;Zhao Zhiyun;Jia Xu;Hou Yanan;Wang Tiange;Li Mian;Lu Jieli;Xu Yu;Chen Yuhong;Qi Lu;Wang Weiqing;Bi Yufang;Xu Min
2型糖尿病(T2D)与抑郁症的高患病率相关。我们的目的是通过执行孟德尔随机化(MR)研究来确定因果关系，该研究使用34个在东亚人中被验证的T2D风险遗传变异作为工具变量(IV)。来自一项大型纵向研究的11506名参与者进行了磁共振分析。T2D遗传风险评分(GRS)是使用34个典型的T2D常见变异建立的。我们使用T2D_GRS作为IV估计量，并进行逆方差加权(IVW)和Egger MR分析。在调整了年龄、性别、体重指数、当前吸烟和饮酒、体育活动、教育程度和婚姻状况后，T2D_GRS与抑郁症相关，OR值为1.21(95%CI：1.07~1.37)。使用T2D_GRS作为IV，我们同样发现了遗传决定的T2D与抑郁症之间的因果关系(OR：1.84，95%CI：1.25-2.70)。虽然我们没有发现T2D的遗传IVs与抑郁症与EggerMR的联合作用(OR：0.95，95%CI：0.42-2.14)，但在排除多基因SNPs后，我们发现T2D与抑郁症与IVW(OR：1.75，95%CI：1.31-2.46)有关。总体而言，MR分析提供了推断T2D和抑郁症之间潜在因果关系的证据。
Type 2 diabetes (T2D) has been associated with a high prevalence of depression.We aimed to determine the causal relation by performing a Mendelian randomization (MR) study using 34 T2D risk genetic variants validated in East Asians as the instrumental variable (IV). An MR analysis was performed involving 11 506 participants from a large longitudinal study. The T2D genetic risk score (GRS) was built using the 34 typical T2D common variants. We used T2D_GRS as the IV estimator and performed inverse-variance weighted (IVW) and Egger MR analysis. The T2D_GRS was found to be associated with depression with an OR of 1.21 (95% CI: 1.07–1.37) after adjustments for age, sex, body mass index, current smoking and drinking, physical activity, education, and marital status. Using T2D_GRS as the IV, we similarly found a causal relationship between genetically determined T2D and depression (OR: 1.84, 95% CI: 1.25–2.70). Though we found no association between the combined effect of the genetic IVs for T2D and depression with EggerMR(OR: 0.95, 95%CI: 0.42–2.14), we found an association for T2D and depression with IVW (OR: 1.75, 95% CI: 1.31–2.46) after excluding pleiotropic SNPs. Overall, the MR analyses provide evidence inferring a potential causal relationship between T2D and depression.
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全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点
影响因子：
30.8
作者：
Cho, Yoon Shin;Chen, Chien-Hsiun;Hu, Cheng;Long, Jirong;Ong, Rick Twee Hee;Sim, Xueling;Takeuchi, Fumihiko;Wu, Ying;Go, Min Jin;Yamauchi, Toshimasa;Chang, Yi-Cheng;Kwak, Soo Heon;Ma, Ronald C. W.;Yamamoto, Ken;Adair, Linda S.;Aung, Tin;Cai, Qiuyin;Chang, Li-Ching;Chen, Yuan-Tsong;Gao, Yutang;Hu, Frank B.;Kim, Hyung-Lae;Kim, Sangsoo;Kim, Young Jin;Lee, Jeannette Jen-Mai;Lee, Nanette R.;Li, Yun;Liu, Jian Jun;Lu, Wei;Nakamura, Jiro;Nakashima, Eitaro;Ng, Daniel Peng-Keat;Tay, Wan Ting;Tsai, Fuu-Jen;Wong, Tien Yin;Yokota, Mitsuhiro;Zheng, Wei;Zhang, Rong;Wang, Congrong;So, Wing Yee;Ohnaka, Keizo;Ikegami, Hiroshi;Hara, Kazuo;Cho, Young Min;Cho, Nam H.;Chang, Tien-Jyun;Bao, Yuqian;Hedman, Asa K.;Morris, Andrew P.;McCarthy, Mark I.;Takayanagi, Ryoichi;Park, Kyong Soo;Jia, Weiping;Chuang, Lee-Ming;Chan, Juliana C. N.;Maeda, Shiro;Kadowaki, Takashi;Lee, Jong-Young;Wu, Jer-Yuarn;Teo, Yik Ying;Tai, E. Shyong;Shu, Xiao Ou;Mohlke, Karen L.;Kato, Norihiro;Han, Bok-Ghee;Seielstad, Mark
通讯作者：
Seielstad, Mark
影响因子：
3.2
作者：
Kato N
通讯作者：
Kato N
影响因子：
4.2
作者：
Cho, Yoon Shin;Lee, Jong-Young;Nho, Chu Won
通讯作者：
Nho, Chu Won
影响因子：
39.2
作者：
Berg, AO;Allan, JD;Woolf, SH
通讯作者：
Woolf, SH
影响因子：
7.7
作者：
M. K. Wium-Andersen;D. D. Ørsted-D.;J. Tolstrup;B. Nordestgaard
通讯作者：
M. K. Wium-Andersen;D. D. Ørsted-D.;J. Tolstrup;B. Nordestgaard