Bi-exponential 3D-T1ρ mapping of whole brain at 3 T.

Bi-exponential 3D-T1ρ mapping of whole brain at 3 T.
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在3 t处的整个大脑的双指数3D-T1ρ映射。

DOI:
10.1038/s41598-018-19452-5
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发表时间:
2018-01-19
期刊:
影响因子:
4.6
通讯作者:
Regatte RR
Regatte RR
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Menon RG;Sharafi A;Windschuh J;Regatte RR

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使用MRI检测多个弛豫池在许多神经病理学中是有用的,包括多发性硬化症(MS)、阿尔茨海默病和中风。在这项研究中,我们评估的可行性,使用T1ρ成像检测的双指数衰减在人脑中。对模型弛豫模型(鸡蛋)和7名健康志愿者进行了前瞻性T1ρ显像研究。使用单池和双池模型拟合数据,分别估计单指数和双指数T1ρ图。脑灰质(GM)和白色(WM)的双指数衰减分别为40.5%和65.1%(P < 0.05)。在大脑中基于T1ρ的双指数衰减的检测为基于T2的对比提供了关于大脑中的体内微环境的补充信息。
Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer’s, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40.5% of GM, and 65.1% of WM pixels showing two T1ρ relaxation pools (significance level P < 0.05). Detection of T1ρ based bi-exponential decays in the brain provides complimentary information to T2 based contrast regarding the in vivo micro-environment in the brain.
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