Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.
Auditory Verb Generation Performance Patterns Dissociate Variants of Primary Progressive Aphasia.
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DOI：
10.3389/fpsyg.2022.887591
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发表时间：
2022
影响因子：
3.8
通讯作者：
Borghesani, Valentina
中科院分区：
文献类型：
--
作者：
Lukic, Sladjana;Licata, Abigail E.;Weis, Elizabeth;Bogley, Rian;Ratnasiri, Buddhika;Welch, Ariane E.;Hinkley, Leighton B. N.;Miller, Z.;Garcia, Adolfo M.;Houde, John F.;Nagarajan, Srikantan S.;Gorno-Tempini, Maria Luisa;Borghesani, Valentina
关键词：
原发性进行性失语症（PPA）是一种临床综合征，患者会逐渐丧失言语和语言能力。目前已确认有三种变体：命名性（lvPPA），与语音和/或短期言语记忆缺陷相关，伴有左侧颞顶叶萎缩；语义性（svPPA），与语义缺陷和前颞叶（ATL）萎缩相关；非流畅性（nfvPPA），与语法和/或言语运动缺陷以及额下回（IFG）萎缩相关。在此，我们着手研究是否能基于单一语言任务中的错误模式区分PPA的这三种变体。我们招募了21名lvPPA患者、28名svPPA患者和24名nfvPPA患者，以及31名健康对照者，并分析了他们在一项听觉名词到动词生成任务中的表现，该任务需要对输入进行听觉分析，获取和选择相关的词汇及语义知识，以及准备和执行言语。三种变体和对照组在任务准确性上存在差异，lvPPA的准确性最低，nfvPPA的准确性最高。关键的是，对不同错误类型的机器学习分析能以高于随机的概率将患者分类到相应的组别。对错误类型的分析揭示了明显的变体特异性效应：lvPPA患者产生“非动词”回答的比例最高，且语义相关名词的数量最多（对名词“球”生成“棒球”而不是“扔”）；相比之下，svPPA患者产生“不相关动词”回答的比例最高，且轻动词的数量最多（对名词“球”生成“拿”而不是“扔”）。综上所述，我们的研究结果表明，听觉动词生成任务中的错误模式与PPA变体中不同神经认知机制的崩溃有关。具体而言，它们证实了颞顶叶区域与词汇加工之间的联系，以及前颞叶与语义过程之间的联系。这些发现说明了对反应模式的分析如何有助于PPA的表型分析并提高诊断敏感性，同时为语言不同成分的神经相关性提供了见解。
Primary progressive aphasia (PPA) is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic (lvPPA), associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic (svPPA), associated with semantic deficits and anterior temporal lobe (ATL) atrophy; non-fluent (nfvPPA) associated with grammar and/or speech-motor deficits and inferior frontal gyrus (IFG) atrophy. Here, we set out to investigate whether the three variants of PPA can be dissociated based on error patterns in a single language task. We recruited 21 lvPPA, 28 svPPA, and 24 nfvPPA patients, together with 31 healthy controls, and analyzed their performance on an auditory noun-to-verb generation task, which requires auditory analysis of the input, access to and selection of relevant lexical and semantic knowledge, as well as preparation and execution of speech. Task accuracy differed across the three variants and controls, with lvPPA and nfvPPA having the lowest and highest accuracy, respectively. Critically, machine learning analysis of the different error types yielded above-chance classification of patients into their corresponding group. An analysis of the error types revealed clear variant-specific effects: lvPPA patients produced the highest percentage of “not-a-verb” responses and the highest number of semantically related nouns (production of baseball instead of throw to noun ball); in contrast, svPPA patients produced the highest percentage of “unrelated verb” responses and the highest number of light verbs (production of take instead of throw to noun ball). Taken together, our findings indicate that error patterns in an auditory verb generation task are associated with the breakdown of different neurocognitive mechanisms across PPA variants. Specifically, they corroborate the link between temporo-parietal regions with lexical processing, as well as ATL with semantic processes. These findings illustrate how the analysis of pattern of responses can help PPA phenotyping and heighten diagnostic sensitivity, while providing insights on the neural correlates of different components of language.
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影响因子：
0.8
作者：
Toller, Gianina;Zitser, Jennifer;Sukhanov, Paul;Grant, Harli;Miller, Bruce L.;Kramer, Joel H.;Rosen, Howard J.;Rankin, Katherine P.;Grinberg, Lea T.
通讯作者：
Grinberg, Lea T.
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9.9
作者：
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通讯作者：
Grossman, Murray
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作者：
Catricala, Eleonora;Polito, Cristina;Perani, Daniela
通讯作者：
Perani, Daniela
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作者：
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通讯作者：
Henry, Maya L.
影响因子：
2.5
作者：
Barde, Laura H. F.;Schwartz, Myrna F.;Boronat, Consuelo B.
通讯作者：
Boronat, Consuelo B.