Sex differences in auditory processing vary across estrous cycle.
Sex differences in auditory processing vary across estrous cycle.
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DOI：
10.1038/s41598-021-02272-5
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发表时间：
2021-11-24
影响因子：
4.6
通讯作者：
Bieszczad KM
中科院分区：
文献类型：
--
作者：
Krizman J;Rotondo EK;Nicol T;Kraus N;Bieszczad KM
在人类中，女性比男性更能处理声音的和声。由于雌激素在季节性繁殖的动物中以性别特异性的方式调节听觉可塑性，因此雌激素信号传导是人类这种差异的一种假设机制。为了研究谐波编码的性别差异在哺乳动物的生殖周期中是否存在相似的变化，我们记录了雄性和雌性大鼠对复杂声音的频率跟随反应（FFR）。在动情周期中循环雌激素水平较低和较高时收集女性 FFR。总体而言，雌性啮齿动物比雄性啮齿动物具有更大的谐波编码，并且在雌性啮齿动物产生更多雌激素期间可以看到更大的谐波强度。这些结果表明，荷尔蒙差异，特别是雌激素，是啮齿动物谐波编码性别差异的基础，并表明类似的机制可能是人类差异的基础。
In humans, females process a sound’s harmonics more robustly than males. As estrogen regulates auditory plasticity in a sex-specific manner in seasonally breeding animals, estrogen signaling is one hypothesized mechanism for this difference in humans. To investigate whether sex differences in harmonic encoding vary similarly across the reproductive cycle of mammals, we recorded frequency-following responses (FFRs) to a complex sound in male and female rats. Female FFRs were collected during both low and high levels of circulating estrogen during the estrous cycle. Overall, female rodents had larger harmonic encoding than male rodents, and greater harmonic strength was seen during periods of greater estrogen production in the females. These results argue that hormonal differences, specifically estrogen, underlie sex differences in harmonic encoding in rodents and suggest that a similar mechanism may underlie differences seen in humans.
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影响因子：
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