Tumor-Derived Small Extracellular Vesicles Involved in Breast Cancer Progression and Drug Resistance.
Tumor-Derived Small Extracellular Vesicles Involved in Breast Cancer Progression and Drug Resistance.
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肿瘤来源的小细胞外囊泡参与乳腺癌进展和耐药性
DOI：
10.3390/ijms232315236
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发表时间：
2022-12-03
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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作者：
乳腺癌是对女性健康最严重和最可怕的威胁之一。最近的研究表明，在肿瘤微环境中，癌细胞本身以及与包括免疫细胞在内的其他细胞之间的相互作用潜在地和内在地调节和决定癌症的进展和转移。细胞外小泡是一种来源于细胞的脂质双层颗粒，其大小小于200 nm，是细胞间通讯的重要介质之一。SEV可以运输各种生物活性物质，包括蛋白质、RNA和脂质。越来越多的证据表明，SEV在癌症的发生发展中起着至关重要的作用，对肿瘤的增殖、侵袭和转移具有重要的影响。此外，SEV系统地协调生理和病理过程，如凝血、血管渗漏和基质细胞重编程，以实现转移前生态位的形成和确定转移器官的趋向性。在肿瘤来源的SEV中，有多种致癌因子在局部间质细胞和远端微环境之间介导细胞通讯，这两个因素在肿瘤的进展和转移中都起着重要的作用。肿瘤来源的SEV含有类似于亲代肿瘤细胞的物质，因此，SEV可能是癌症进展的生物标记物和潜在的治疗靶点，特别是对于预测和预防未来的转移发展。在这里，我们回顾了肿瘤来源的SEV对肿瘤发生和发展的调节机制，包括增殖、转移、耐药和免疫抑制，这些机制协调地塑造了促进转移的微环境。此外，我们描述了SEV在癌症生物标记物和潜在治疗方式的开发中的应用，并讨论了如何将它们设计并转化为临床实践。
Breast cancer is one of the most serious and terrifying threats to the health of women. Recent studies have demonstrated that interaction among cancer cells themselves and those with other cells, including immune cells, in a tumor microenvironment potentially and intrinsically regulate and determine cancer progression and metastasis. Small extracellular vesicles (sEVs), a type of lipid-bilayer particles derived from cells, with a size of less than 200 nm, are recognized as one form of important mediators in cell-to-cell communication. sEVs can transport a variety of bioactive substances, including proteins, RNAs, and lipids. Accumulating evidence has revealed that sEVs play a crucial role in cancer development and progression, with a significant impact on proliferation, invasion, and metastasis. In addition, sEVs systematically coordinate physiological and pathological processes, such as coagulation, vascular leakage, and stromal cell reprogramming, to bring about premetastatic niche formation and to determine metastatic organ tropism. There are a variety of oncogenic factors in tumor-derived sEVs that mediate cellular communication between local stromal cells and distal microenvironment, both of which are important in cancer progression and metastasis. Tumor-derived sEVs contain substances that are similar to parental tumor cells, and as such, sEVs could be biomarkers in cancer progression and potential therapeutic targets, particularly for predicting and preventing future metastatic development. Here, we review the mechanisms underlying the regulation by tumor-derived sEVs on cancer development and progression, including proliferation, metastasis, drug resistance, and immunosuppression, which coordinately shape the pro-metastatic microenvironment. In addition, we describe the application of sEVs to the development of cancer biomarkers and potential therapeutic modalities and discuss how they can be engineered and translated into clinical practice.
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DOI：
10.1016/j.jconrel.2015.07.030
发表时间：
2015-12-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Batrakova EV;Kim MS
通讯作者：
Kim MS
影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
影响因子：
9.5
作者：
Cao, Thuy Giang Nguyen;Kang, Ji Hee;Shim, Min Suk
通讯作者：
Shim, Min Suk
影响因子：
50.3
作者：
Becker A;Thakur BK;Weiss JM;Kim HS;Peinado H;Lyden D
通讯作者：
Lyden D
影响因子：
7.3
作者：
Schwich E;Rebmann V
通讯作者：
Rebmann V