Diabetes and breast cancer mortality in Black women.
Diabetes and breast cancer mortality in Black women.
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DOI：
10.1007/s10552-016-0837-z
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Palmer JR
中科院分区：
文献类型：
--
作者：
Charlot M;Castro-Webb N;Bethea TN;Bertrand K;Boggs DA;Denis GV;Adams-Campbell LL;Rosenberg L;Palmer JR
黑人妇女的乳腺癌死亡率高于白色妇女。2型糖尿病的患病率也较高，但缺乏关于糖尿病是否影响这一人群乳腺癌死亡率的数据。我们在黑人妇女健康研究中调查了乳腺癌诊断时糖尿病与乳腺癌死亡率的关系，这是一项前瞻性队列研究。1995年至2013年诊断为浸润性乳腺癌的1，621名黑人妇女通过邮寄问卷和国家死亡指数搜索进行了跟踪调查。多变量考克斯回归分析用于计算糖尿病与乳腺癌死亡率和全因死亡率相关的风险比（HR），并调整年龄、分期、治疗方式、雌激素受体（ER）状态和体重指数。随访期间有368人死亡，其中273人死于乳腺癌。在乳腺癌发生前至少5年被诊断患有糖尿病的女性中，乳腺癌死亡率显著增加，HR 1.86（95% CI 1.20-2.89），观察到ER+和ER−乳腺癌均升高。糖尿病患者的全因死亡率也更高，总体HR为1.54（95% CI 1.12-2.07），糖尿病病程≥5年的HR为2.26（95% CI 1.62-3.15）。我们的研究结果首次提供了黑人女性2型糖尿病与乳腺癌死亡率呈正相关的确凿证据。鉴于黑人妇女中2型糖尿病的患病率较高且发病较早，糖尿病可能导致乳腺癌死亡率的种族差异。
Breast cancer mortality is higher in Black women than in White women. The prevalence of type 2 diabetes mellitus is also higher, yet data on whether diabetes affects breast cancer mortality in this population are lacking. We investigated the relation of diabetes at the time of breast cancer diagnosis to breast cancer mortality in the Black Women’s Health Study, a prospective cohort study. 1,621 Black women with invasive breast cancer diagnosed in 1995–2013 were followed by mailed questionnaires and searches of the National Death Index. Multivariable Cox regression analysis was used to compute hazard ratios (HRs) for diabetes in relation to breast cancer mortality and all-cause mortality, with adjustment for age, stage, treatment modality, estrogen receptor (ER) status, and body mass index. There were 368 deaths during follow-up, of which 273 were due to breast cancer. Breast cancer mortality was significantly increased in women who had been diagnosed with diabetes at least 5 years before breast cancer occurrence, HR 1.86 (95% CI 1.20–2.89), with elevations observed for both ER+ and ER− breast cancer. All-cause mortality was also higher in diabetics, with HRs of 1.54 (95% CI 1.12–2.07) overall and 2.26 (95% CI 1.62–3.15) for ≥5-year duration of diabetes relative to non-diabetics. Our results present the first solid evidence of a positive association of type 2 diabetes with breast cancer mortality in Black women. Given the higher prevalence and earlier onset of type 2 diabetes in Black women, it is likely that diabetes contributes to racial disparities in breast cancer mortality.
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影响因子：
3.8
作者：
Patterson, Ruth E.;Flatt, Shirley W.;Saquib, Nazmus;Rock, Cheryl L.;Caan, Bette J.;Parker, Barbara A.;Laughlin, Gail A.;Erickson, Kirsten;Thomson, Cynthia A.;Bardwell, Wayne A.;Hajek, Richard A.;Pierce, John P.
通讯作者：
Pierce, John P.
影响因子：
6.2
作者：
Liu, Xiangdong;Ji, Jianguang;Hemminki, Kari
通讯作者：
Hemminki, Kari
影响因子：
5
作者：
Coughlin, SS;Calle, EE;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
45.3
作者：
Goodwin, PJ;Ennis, M;Hood, N
通讯作者：
Hood, N
糖尿病，糖尿病治疗和乳腺癌预后。
影响因子：
3.8
作者：
Luo, Juhua;Virnig, Beth;Hendryx, Michael;Wen, Sijin;Chelebowski, Rowan;Chen, Chu;Rohan, Tomas;Tinker, Lesley;Wactawski-Wende, Jean;Lessin, Lawrence;Margolis, Karen
通讯作者：
Margolis, Karen