Medical comorbidities predict mortality in women with a history of early stage breast cancer.
Medical comorbidities predict mortality in women with a history of early stage breast cancer.
复制标题
DOI：
10.1007/s10549-010-0732-3
复制
发表时间：
2010-08
影响因子：
3.8
通讯作者：
Pierce, John P.
中科院分区：
文献类型：
--
作者：
Patterson, Ruth E.;Flatt, Shirley W.;Saquib, Nazmus;Rock, Cheryl L.;Caan, Bette J.;Parker, Barbara A.;Laughlin, Gail A.;Erickson, Kirsten;Thomson, Cynthia A.;Bardwell, Wayne A.;Hajek, Richard A.;Pierce, John P.
进行这项分析是为了确定合并症医疗状况是否可以预测有早期乳腺癌病史的女性的额外乳腺癌事件和全因死亡率。参与随机饮食试验的女性 (n=2542) 完成了一份自填问卷，内容涉及她们目前是否正在接受多种疾病（心血管、糖尿病、胆囊、胃肠道、关节炎和骨质疏松症）和状况（高血压、胆固醇水平升高）的治疗。身高和体重是在基线时测量的。参与者的随访时间中位数为 7.3 年（范围 0.8 至 15.0）。进行 Cox 回归分析以评估合并症是否可以预测无病生存期和总生存期；风险比（HR）是关联性的衡量标准。总体而言，新增 406 例乳腺癌事件和 242 例死亡。患有糖尿病的参与者发生额外乳腺癌事件（HR 2.1，95% CI：1.3，3.4）和死亡率（HR 2.5，95% CI：1.4，4.4）的风险是其两倍以上。多种合并症的存在并不能在统计学上显着预测额外的乳腺癌事件。然而，与没有合并症的参与者相比，患有 3 种或更多合并症的参与者的 HR 为 2.1，死亡率的 95% CI：1.3、3.3。 2 型糖尿病与乳腺癌预后不良相关。鉴于 85% 的死亡是由乳腺癌引起的，这些研究结果表明，多种合并症可能会降低其他乳腺癌事件中幸存的可能性。
This analysis was conducted to determine whether comorbid medical conditions predict additional breast cancer events and all-cause mortality in women with a history of early stage breast cancer. Women (n=2542) participating in a randomized diet trial completed a selfadministered questionnaire regarding whether they were currently being treated for a wide variety of diseases (cardiovascular, diabetes, gallbladder, gastrointestinal, arthritis, and osteoporosis) and conditions (high blood pressure, elevated cholesterol level). Height and weight were measured at baseline. Participants were followed for a median of 7.3 years (range 0.8 to 15.0). Cox regression analysis was performed to assess whether comorbidities predicted disease-free and overall survival; hazard ratio (HR) was the measure of association. Overall, there were 406 additional breast cancer events and 242 deaths. Participants with diabetes had over 2-fold the risk of additional breast cancer events (HR 2.1, 95% CI: 1.3, 3.4) and mortality (HR 2.5, 95% CI: 1.4, 4.4). The presence of multiple comorbidities did not statistically significantly predict additional breast cancer events. However, compared to no comorbidities, participants with 3 or more comorbidities had a HR of 2.1, 95% CI: 1.3, 3.3 for mortality. Type 2 diabetes was associated with poor breast cancer prognosis. Given that 85 percent of deaths were caused by breast cancer, these findings suggest that multiple comorbidities may reduce the likelihood of surviving additional breast cancer events.
登录
查看更多内容
影响因子：
4
作者：
Klein, BEK;Klein, R;Lee, KE
通讯作者：
Lee, KE
影响因子：
6.9
作者：
McTiernan, Anne;Wu, LieLing;Wang, C. Y.
通讯作者：
Wang, C. Y.
影响因子：
16.2
作者：
Michels, KB;Solomon, CG;Manson, JE
通讯作者：
Manson, JE
影响因子：
6.4
作者：
Braithwaite, Dejana;Tammemagi, C. Martin;Esserman, Laura
通讯作者：
Esserman, Laura
影响因子：
3
作者：
Chaudhry, S;Jin, L;Meltzer, D
通讯作者：
Meltzer, D