A Dynamic Network Simulation of the Nematode Tap Withdrawal Circuit: Predictions Concerning Synaptic Function Using Behavioral Criteria
A Dynamic Network Simulation of the Nematode Tap Withdrawal Circuit: Predictions Concerning Synaptic Function Using Behavioral Criteria
复制标题
线虫抽头撤回回路的动态网络模拟：使用行为标准预测突触功能
作者：
S. R. Wicks;C. Roehrig;C. Rankin
线虫的抽头反射显示了几种形式的行为可塑性。尽管支持这种行为的神经连通性已被确定（秀丽隐杆线虫机械感觉刺激的整合，Wicks和Rankin， 1995, J Neurosci 15:2434-2444），但神经递质表型，以及回路中的突触是兴奋性还是抑制性，仍未得到表征。在这里，我们使用一种新颖的策略来预测极性配置，即兴奋性和抑制性连接的阵列，线虫抽头退出电路使用解剖学和生理学上合理的动态网络模拟该电路。模型电路的输出被优化到符合动物的行为，通过详尽地列举构成模型电路的突触信号阵列，动物拥有因手术消融而改变的电路。然后比较所有可能的极性配置，并使用统计分析来确定，对于给定的突触类，特定极性是否与行为数据良好匹配。四个相关实验的结果被用来预测九类抽头提取电路中七类细胞的极性。此外，该模型还用于评估两种新型机械感觉统合神经元：DVA和PVD的可能作用。
The nematode tap withdrawal reflex demonstrates several forms of behavioral plasticity. Although the neural connectivity that supports this behavior is identified (Integration of mechanosensory stimuli in Caenorhabditis elegans, Wicks and Rankin, 1995, J Neurosci 15:2434–2444), the neurotransmitter phenotypes, and hence whether the synapses in the circuit are excitatory or inhibitory, remain uncharacterized. Here we use a novel strategy to predict the polarity configuration, i.e., the array of excitatory and inhibitory connections, of the nematode tap withdrawal circuit using an anatomically and physiologically justifiable dynamic network simulation of that circuit. The output of the modeled circuit was optimized to the behavior of animals, which possessed circuits altered by surgical ablation by exhaustively enumerating an array of synaptic signs that constituted the modeled circuit. All possible polarity configurations were then compared, and a statistical analysis was used to determine whether, for a given synaptic class, a particular polarity was associated with a good fit to behavioral data. The results from four related experiments were used to predict the polarities of seven of the nine cell classes of the tap withdrawal circuit. In addition, the model was used to assess possible roles for two novel mechanosensory integration neurons: DVA and PVD.
登录
查看更多内容
影响因子：
2.5
作者：
DeSchutter,E;Angstadt,JD;Calabrese,RL
通讯作者：
Calabrese,RL
影响因子：
56.9
作者：
HORVITZ, HR;CHALFIE, M;EVANS, PD
通讯作者：
EVANS, PD
秀丽隐杆线虫 cAMP 依赖性蛋白激酶催化亚基基因的克隆、表征和表达。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Gross,RE;Bagchi,S;Lu,X;Rubin,CS
通讯作者：
Rubin,CS
秀丽隐杆线虫 cAMP 依赖性蛋白激酶新型调节亚基基因的克隆、结构和表达。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Lu,XY;Gross,RE;Bagchi,S;Rubin,CS
通讯作者：
Rubin,CS
影响因子：
13.9
作者：
S. Lac;Jennifer;L. Raymond;T. J. Sejnowskiz;S. Lisberger
通讯作者：
S. Lac;Jennifer;L. Raymond;T. J. Sejnowskiz;S. Lisberger