Acute adverse effects of fine particulate air pollution on ventricular repolarization.
Acute adverse effects of fine particulate air pollution on ventricular repolarization.
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DOI：
10.1289/ehp.0901648
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发表时间：
2010-07
影响因子：
10.4
通讯作者：
Cascio WE
中科院分区：
文献类型：
--
作者：
Liao D;Shaffer ML;Rodriguez-Colon S;He F;Li X;Wolbrette DL;Yanosky J;Cascio WE
颗粒物污染与心脏病之间的关系机制尚未完全了解。我们研究了暴露于空气动力学直径≤ 2.5 μm的细颗粒物（PM2.5）对106名居住在宾夕法尼亚州中部社区的非吸烟成年人心室复极的影响和时间过程。使用高分辨率12导联霍尔特系统获得24小时逐搏心电图（ECG）数据。在视觉识别和去除伪影和心搏后，我们总结了每个30分钟段的正常心搏QT间期，作为心率（HR）校正QT测量值：QT延长指数（QTI）、Bazett的HR校正QT（QTcB）和Fridericia的HR校正QT（QTcF）。使用个人PM2.5监测仪测量个人水平的实时PM2.5暴露24小时。我们平均这些数据，并使用30分钟特定时间的平均PM2.5暴露。参与者的平均年龄为56 ± 8岁，其中41%为男性，74%为白色。QTI、QTcB和QTcF的平均值± SD分别为111 ± 6.6、438 ± 23 msec和422 ± 22 msec; PM2.5的平均值± SD为14 ± 22 μg/m3。我们在线性混合效应模型的框架下使用分布滞后模型来评估30分钟PM2.5和HR校正QT测量值之间的自相关校正回归系数（β）。PM2.5暴露对心室复极的不利影响大多发生在3-4小时内。QTI、QTcB和QTcF的滞后7 PM 2.5增加10 μg/m3所致的（SE，p值）为0.08（0.04，p < 0.05）、0.22（0.08，p < 0.01）和0.09（0.05，p < 0.05）。我们的研究结果表明PM2.5对心室复极有显著的不利影响。效果的时间过程是在PM2.5升高的3-4小时内。
The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) on ventricular repolarization of 106 nonsmoking adults who were living in communities in central Pennsylvania. The 24-hr beat-to-beat electrocardiogram (ECG) data were obtained using a high-resolution 12-lead Holter system. After visually identifying and removing artifacts and arrhythmic beats, we summarized normal beat-to-beat QTs from each 30-min segment as heart rate (HR)-corrected QT measures: QT prolongation index (QTI), Bazett’s HR-corrected QT (QTcB), and Fridericia’s HR-corrected QT (QTcF). A personal PM2.5 monitor was used to measure individual-level real-time PM2.5 exposures for 24 hr. We averaged these data and used 30-min time-specific average PM2.5 exposures. The mean age of the participants was 56 ± 8 years, with 41% male and 74% white. The means ± SDs for QTI, QTcB, and QTcF were 111 ± 6.6, 438 ± 23 msec, and 422 ± 22 msec, respectively; and for PM2.5, the mean ± SD was 14 ± 22 μg/m3. We used distributed lag models under a framework of linear mixed-effects models to assess the autocorrelation-corrected regression coefficients (β) between 30-min PM2.5 and the HR-corrected QT measures. Most of the adverse ventricular repolarization effects from PM2.5 exposure occurred within 3–4 hr. The multivariable adjusted β (SE, p-value) due to a 10-μg/m3 increase in lag 7 PM2.5 on QTI, QTcB, and QTcF were 0.08 (0.04, p < 0.05), 0.22 (0.08, p < 0.01), and 0.09 (0.05, p < 0.05), respectively. Our results suggest a significant adverse effect of PM2.5 on ventricular repolarization. The time course of the effect is within 3–4 hr of elevated PM2.5.
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影响因子：
10.4
作者：
Dockery DW;Luttmann-Gibson H;Rich DQ;Link MS;Mittleman MA;Gold DR;Koutrakis P;Schwartz JD;Verrier RL
通讯作者：
Verrier RL
影响因子：
2.8
作者：
GOLDBERG, RJ;BENGTSON, J;LEVY, D
通讯作者：
LEVY, D
影响因子：
24
作者：
Rautaharju, Pentti M.;Surawicz, Borys;Gettes, Leonard S.
通讯作者：
Gettes, Leonard S.
DOI：
10.1097/ede.0b013e3181812bb7
发表时间：
2008-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Franklin M;Koutrakis P;Schwartz P
通讯作者：
Schwartz P
影响因子：
10.4
作者：
Liao, DP;Creason, J;Zweidinger, R
通讯作者：
Zweidinger, R