Ten things you should know about transposable elements.

Ten things you should know about transposable elements.
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DOI:
10.1186/s13059-018-1577-z
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发表时间:
2018-11-19
期刊:
影响因子:
12.3
通讯作者:
Feschotte C
Feschotte C
中科院分区:
生物学1区
文献类型:
--
作者:
Bourque G;Burns KH;Gehring M;Gorbunova V;Seluanov A;Hammell M;Imbeault M;Izsvák Z;Levin HL;Macfarlan TS;Mager DL;Feschotte C

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转座因子是真核生物基因组的重要组成部分。然而,它们对基因组进化,功能和疾病的影响程度仍然是一个激烈的问题。基因组学和大规模功能检测的兴起为TE的多方面活动提供了新的视角,并意味着它们不应再被边缘化。在这里,我们介绍了TE的基本特性及其与细胞环境的复杂相互作用,这对于理解它们对生物体生物学的影响和多种后果至关重要。虽然我们主要从哺乳动物系统中提取例子,但这里概述的核心概念与广泛的生物体相关。
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
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