Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders.
Bone morphogenetic protein-15 in follicle fluid combined with age may differentiate between successful and unsuccessful poor ovarian responders.
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卵泡液中的骨形态发生蛋白 15 与年龄相结合可以区分成功和不成功的卵巢反应不良者
DOI：
10.1186/1477-7827-10-116
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发表时间：
2012-12-26
期刊：
影响因子：
--
通讯作者：
Huang HF
中科院分区：
文献类型：
--
作者：
Wu YT;Wang TT;Chen XJ;Zhu XM;Dong MY;Sheng JZ;Xu CM;Huang HF
背景卵巢反应不良者的妊娠可能性咨询一直是妇科医生的难题。本研究的目的是通过调查卵母细胞衍生因子骨形态发生蛋白-15（BMP-15）结合实际年龄在预测体外受精-胚胎移植（IVF-ET）在反应不良的结果中的作用来优化反应不良者的管理。从2008年7月1日至2009年12月31日，共招募了207名在取卵当天接受IVF/胞浆内单精子注射（ICSI）的卵巢低反应者，其中3个或更少卵泡不小于14 mm。另选择215个反应正常的同步周期作为对照。通过蛋白质印迹法分析207例低反应者卵泡液（FF）中BMP-15的水平。根据FF BMP-15水平和年龄，将不良反应者分为四组。主要结果指标为FF BMP-15水平、种植率、妊娠率和活产率。（24.2% vs. 15.3%），化学妊娠率（40%对23.7%），临床妊娠率高BMP-15组的妊娠率（36.5%vs20.4%）和活产率（29.4%vs15.1%）显著高于低BMP-15组。此外，不良反应者年龄小于或等于35岁，具有较高的FF BMP-15水平有最好的植入，怀孕和活产率，这是与正常responders.ConclusionsOur研究表明，BMP-15在预测IVF结局的潜在作用。高FF BMP-15结合年龄小于或等于35岁可用作卵巢反应不良者重复IVF周期的潜在指标。
BackgroundThe counselling of poor ovarian responders about the probability of pregnancy remains a puzzle for gynaecologists. The aim of this study was to optimise the management of poor responders by investigating the role of the oocyte-derived factor bone morphogenetic protein-15 (BMP-15) combined with chronological age in the prediction of the outcome of in-vitro fertilisation-embryo transfer (IVF-ET) in poor responders.MethodsA retrospective study conducted in a university hospital. A total of 207 poor ovarian responders who reached the ovum pick-up stage undergoing IVF/intracytoplasmic sperm injection (ICSI) with three or fewer follicles no less than 14 mm on the day of oocyte retrieval were recruited from July 1, 2008 to December 31, 2009. Another 215 coinstantaneous cycles with normal responses were selected as controls. The BMP-15 levels in the follicular fluid (FF) of the 207 poor responders were analysed by western blot. Based on the FF BMP-15 level and age, poor responders were sub-divided into four groups. The main outcome measures were the FF BMP-15 level, implantation rate, pregnancy rate, and live birth rate.ResultsThe implantation rate (24.2% vs. 15.3%), chemical pregnancy rate (40% vs. 23.7%), clinical pregnancy rate (36.5% vs. 20.4%) and live birth rate (29.4% vs. 15.1%) in the high BMP-15 group were significantly higher than those in the low BMP-15 group. Furthermore, poor responders aged less than or equal to 35 years with a higher FF BMP-15 level had the best implantation, pregnancy and live birth rates, which were comparable with those of normal responders.ConclusionsOur study suggests a potential role of BMP-15 in the prediction of the IVF outcome. A high FF BMP-15 combined with an age less than or equal to 35 years may be used as a potential indicator for repeating IVF cycles in poor ovarian responders.
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影响因子：
1.7
作者：
Kuliev, A;Cieslak, J;Verlinsky, Y
通讯作者：
Verlinsky, Y
影响因子：
4.8
作者：
Otsuka, F;Yamamoto, S;Shimasaki, S
通讯作者：
Shimasaki, S
影响因子：
2.6
作者：
Moron, Francisco J.;de Castro, Francisco;Ruiz, Agustin
通讯作者：
Ruiz, Agustin
影响因子：
6.7
作者：
Verpoest, WMJA;Cahill, DJ;Hull, MGR
通讯作者：
Hull, MGR
DOI：
10.1073/pnas.0600507103
发表时间：
2006-07-11
影响因子：
11.1
作者：
Yoshino, Osamu;McMahon, Heather E.;Shimasaki, Shunichi
通讯作者：
Shimasaki, Shunichi